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Highly efficient one-step microwave-assisted synthesis of structurally diverse bis-substituted α-amino acid derived diimides.

ABSTRACT: We report herein a facile and widely applicable microwave-assisted protocol for the synthesis of symmetrical diimides based on three structurally distinct aromatic dianhydrides: pyromellitic (PMA), biphenyl-tetracarboxylic acid (BPDA) and benzophenone-tetracarboxylic (BTDA) and five natural amino acids (Phe, Tyr, Ile, Lys, Cys). Fifteen symmetrical diimides with different structural characteristics containing a variety of functional groups can be produced with high yields and on a large scale.

SUBMITTER: Konopka M

PROVIDER: S-EPMC9085299 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Highly efficient one-step microwave-assisted synthesis of structurally diverse bis-substituted α-amino acid derived diimides.

Konopka Marcin M Markiewicz Grzegorz G Stefankiewicz Artur R AR

RSC advances 20180823 52

We report herein a facile and widely applicable microwave-assisted protocol for the synthesis of symmetrical diimides based on three structurally distinct aromatic dianhydrides: pyromellitic (PMA), biphenyl-tetracarboxylic acid (BPDA) and benzophenone-tetracarboxylic (BTDA) and five natural amino acids (Phe, Tyr, Ile, Lys, Cys). Fifteen symmetrical diimides with different structural characteristics containing a variety of functional groups can be produced with high yields and on a large scale. ...[more]

PMID: 35547322

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