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A facile route to magnetic mesoporous core-shell structured silicas containing covalently bound cyclodextrins for the removal of the antibiotic doxycycline from water.

ABSTRACT: The excessive use of antibiotics has led to various environmental problems; the control and separation of these antibiotics are important in environmental science. Herein, a novel mesoporous nanocomposite, Fe₃O₄@SiO₂@mSiO₂-CD, has been synthesized for the removal of antibiotic compounds from aqueous media. The well-designed nanocomposite is composed of β-cyclodextrin functionalized surfaces, ordered mesoporous silica shells with large radially oriented mesopores, and nonporous silica-coated magnetic cores (Fe₃O₄). The synergistic action of both the mesoporous structure and the accessible cavity of β-cyclodextrin ensures the good adsorption of doxycycline. Furthermore, the Fe₃O₄@SiO₂@mSiO₂-CD nanocomposite can be collected, separated and easily recycled from aqueous solution using an external magnet.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC9085906 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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A facile route to magnetic mesoporous core-shell structured silicas containing covalently bound cyclodextrins for the removal of the antibiotic doxycycline from water.

Zhang Ying Y Jiang Fuquan F Huang Danya D Hou Shushan S Wang Hongli H Wang Minggang M Chi Yue Y Zhao Zhankui Z

RSC advances 20180905 55

The excessive use of antibiotics has led to various environmental problems; the control and separation of these antibiotics are important in environmental science. Herein, a novel mesoporous nanocomposite, Fe3O4@SiO2@mSiO2-CD, has been synthesized for the removal of antibiotic compounds from aqueous media. The well-designed nanocomposite is composed of β-cyclodextrin functionalized surfaces, ordered mesoporous silica shells with large radially oriented ...[more]

PMID: 35548251

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Project description:Background: Polymer-coated mesoporous silica nanoparticles have attracted immense research interest in stimuli-responsive drug delivery systems due to their drug-releasing ability on demand at specific sites in response to external or internal signals. However, the relationships between the coated-copolymer encapsulation and drug delivery performance in the hybrid nanocomposites was rarely reported. Therefore, the main objectives of the present work are to explore the cell uptake, cellular internalization, cytotoxicity, and hemolysis performance of the fluorescent hybrid materials with different polymer-encapsulated amounts. Methods: Using (2-(2-aminoethyl)-6-(dimethylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione)-doped poly[(N-isopropylacrylamide)-co-(acrylic acid)] (PAN) as a shell and bimodal mesoporous silicas (BMMs) as a core, the dual pH- and temperature-responsive mesoporous PAN@M-BMMs with the fluorescent performances were synthesized via a radical polymerization approach. The effects of the PAN-coated thicknesses on their physicochemical properties and structural features were demonstrated via XRD and SAXS patterns, SEM and TEM images, FT-IR spectra, and TG analysis. Their mass fractal (Dm) evolutions were elucidated on the basis of the SAXS patterns and fluorescence spectra. Results: The Dm values increased from 2.74 to 2.87 with an increase of the PAN-coated amount from 17 to 26.5% along with the particle size from 76.1 to 85.6 nm and blue-shifting of their fluorescent emission wavelength from 470 to 444 nm. Meanwhile, the PAN@M-BMMs exhibited a high ibuprofen (IBU) loading capacity (13.8%) and strong dual pH-/temperature-responsive drug-releasing performances (83.1%) at pH 7.4 and 25 °C, as comparison with that (17.9%) at pH 2.0 and 37 °C. The simulated results confirmed that the adsorption energy decreased from -67.18 kJ/mol for pure BMMs to -116.76 kJ/mol for PAN@M-BMMs, indicating the PAN-grafting on the surfaces of the BMMs core was beneficial to improve its IBU-adsorption capacity. Its uptake in the HeLa cell line was performed via microplate readers, confocal microscopy, flow cytometry, and ICP measurement, showing a low cytotoxicity at a concentration up to 100 µg/mL. Specially, P0.2AN@M-BMMs had a superior cellular uptake and fluorescence properties via the time-dependent uptake experiments, and exhibited the highest silicon content via the cellular internalization analysis, as compared to other carriers. Hemolysis tests confirmed the hemolysis rates below 5%. Conclusions: These demonstrations verified that PAN@M-BMMs should be a promising biomedical application prospect.

Dataset Information

A facile route to magnetic mesoporous core-shell structured silicas containing covalently bound cyclodextrins for the removal of the antibiotic doxycycline from water.

Publications

A facile route to magnetic mesoporous core-shell structured silicas containing covalently bound cyclodextrins for the removal of the antibiotic doxycycline from water.

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