Unknown

Dataset Information

0

Evolution of TEM-related extended-spectrum beta-lactamases in Korea.


ABSTRACT: TEM-52, differing from TEM-1 by having the substitutions Glu-104-->Lys, Met-182-->Thr, and Gly-238-->Ser, has previously been described as the most prevalent extended-spectrum beta-lactamase (ESBL) in Korea. In a further survey, we discovered the ESBLs TEM-15, which is like TEM-52 but lacks the substitution at residue 182, and TEM-88, which is like TEM-52 with an additional Gly-196-->Asp substitution. TEM-88 retained the activity of TEM-52 against moxalactam. Otherwise, the kinetic properties of the three ESBLs failed to show an advantage to this evolution.

SUBMITTER: Pai H 

PROVIDER: S-EPMC90891 | biostudies-literature | 2001 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Evolution of TEM-related extended-spectrum beta-lactamases in Korea.

Pai H H   Lee H J HJ   Choi E H EH   Kim J J   Jacoby G A GA  

Antimicrobial agents and chemotherapy 20011201 12


TEM-52, differing from TEM-1 by having the substitutions Glu-104-->Lys, Met-182-->Thr, and Gly-238-->Ser, has previously been described as the most prevalent extended-spectrum beta-lactamase (ESBL) in Korea. In a further survey, we discovered the ESBLs TEM-15, which is like TEM-52 but lacks the substitution at residue 182, and TEM-88, which is like TEM-52 with an additional Gly-196-->Asp substitution. TEM-88 retained the activity of TEM-52 against moxalactam. Otherwise, the kinetic properties of  ...[more]

Similar Datasets

| S-EPMC1087658 | biostudies-literature
| S-EPMC89239 | biostudies-literature
| S-EPMC166109 | biostudies-literature
| S-EPMC3032993 | biostudies-literature
| S-EPMC2151416 | biostudies-literature
| S-EPMC3586863 | biostudies-literature
| S-EPMC2725898 | biostudies-literature
| S-EPMC2916347 | biostudies-literature
| S-EPMC10135299 | biostudies-literature
| S-EPMC163097 | biostudies-other