Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Schiff base capped gold nanoparticles for transition metal cation sensing in organic media.

ABSTRACT: We report a fast and ultrasensitive colorimetric method for the detection of transition metal ions (Fe³⁺, Cu²⁺, Ni²⁺) in a mixture of toluene-acetonitrile using Schiff base functionalized gold nanoparticles. We achieved limits of detection for the three metal ions at least two orders of magnitude lower than the EU recommended limits. Finally, our methodology was assessed for the determination of nickel in the organic waste of a relevant industrial reaction.

SUBMITTER: Conkova M

PROVIDER: S-EPMC9089317 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Schiff base capped gold nanoparticles for transition metal cation sensing in organic media.

Čonková Miroslava M Montes-García Verónica V Konopka Marcin M Ciesielski Artur A Samori Paolo P Stefankiewicz Artur R AR

Chemical communications (Cambridge, England) 20220510 38

We report a fast and ultrasensitive colorimetric method for the detection of transition metal ions (Fe3+, Cu2+, Ni2+) in a mixture of toluene-acetonitrile using Schiff base functionalized gold nanoparticles. We achieved limits of detection for the three metal ions at least two orders of magnitude lower than the EU recommended limits. Finally, our methodology was assessed for the determination of nickel in the organic waste of a relevant industrial reaction. ...[more]

PMID: 35451443

Similar Datasets

Bioactive Salen-type Schiff Base Transition Metal Complexes as Possible Anticancer Agents.

Project description:Although metal-based anticancer drugs have been recognized as the most effective agents over the organic compounds, non-selectivity and high toxic effects have limited their applications in a way that only three Pt-analogues have progressed into clinical use. These problems have spurred chemists to develop different strategies based on alternative targets. This work focuses on predicting potency and mode of interactions of a series of salen type Schiff base transition metal complexes derived from meso-1,2-diphenyl-1,2-ethylenediamine, over some proteins (HDAC7, HDAC2, CatB, B-RAF kinase, TopII, RNR, TS, and rHA) using computational docking method, to be later considered as possible anticancer agents. The obtained results showed that all complexes exhibited higher affinity for HDAC7 than the other targets. Moreover, the bromo-derivatives of the copper compounds were more active on HDAC7 than the other derivatives. Such bromo compounds showed considerable interactions with Kinase, RNR, TS, and CatB. Contrary to Histone deacetylase (HAD)C7; HDAC2 was predicted to be relatively poor target. As expected, formation of the hydrophobic interactions between the metal complexes and the protein targets were essential for activity of the metal compounds. This study provides some more information for further optimizations and development of new metallodrugs as enzyme inhibitors for potential therapeutic agents.

| S-EPMC7059031 | biostudies-literature

Chemical, Pharmacological, and Theoretical Aspects of Some Transition Metal(II) Complexes Derived from Pyrrole Azine Schiff Base.

Project description:Some new transition metal complexes were prepared by reacting metal(II) salts with Schiff base azines, which were prepared via condensation of 5-(diethylamino) salicylaldehyde and hydrazine with pyrrole-2-carbaldehyde. Their structures were confirmed based on CHN, UV-visible, FT-IR, and EPR measurements. The complexes were also assessed for their antibacterial, antioxidant, and anticancer properties. Some of these chemicals were said to be extraordinarily effective in this respect. The antibacterial activities of the complexes in vitro demonstrated their potential, although the [Cu(L)(bpy] complex was suggested to exhibit moderate activity against pathogens compared to all other in this series. The cytotoxic activity of the prepared analogues showed better cell viability compared with standard cisplatin. Moreover, there is a good agreement between the experimental and theoretical findings from docking and theoretical investigations done using DFT at the B3LYP level.

| S-EPMC10536097 | biostudies-literature

Palladium Schiff base complex-modified Cu(BDC-NH2) metal-organic frameworks for C-N coupling.

Project description:In this study, the synthesis of a novel functionalized metal-organic-framework (MOF) [Cu(BDC-NH2)@Schiff-base-Pd(ii)] catalyst via post-synthetic modification of Cu(BDC-NH2) is reported. The targeted complex was prepared by chemically attaching N,N'-bis(5-formylpyrrol-2-ylmethyl) homopiperazine via a Schiff base reaction followed by complexation with Pd ions. Afterwards, the synthesized solid was applied as a very effective multifunctional catalyst in C-N coupling reactions. The synthesized compounds were identified by suitable techniques including N2 isotherms, EDX spectroscopy, FT-IR spectroscopy, XRD, SEM, ICP-OES and TG-DTA. This nanocatalyst was used in C-N cross-coupling reactions, and it showed its usage in a diverse range of different functional groups with good efficiency. The reasons for introducing this catalyst system are its advantages such as considerably high selectivity, almost complete conversion of products, high yields, and convenient separation of catalysts and products. The results indicate that the highest efficiency of the product in the reaction was obtained in the shortest possible time with the use of [Cu(BDC-NH2)@Schiff-base-Pd(ii)] catalysts. Overall, the high catalytic activity of the [Cu(BDC-NH2)@Schiff-base-Pd(ii)] catalyst may be due to the obtained high surface area and the synergistic features created between Lewis acidic Cu nodes and Pd ions.

| S-EPMC10014173 | biostudies-literature

Metal-organic framework (MOF) hybridized gold nanoparticles as a bifunctional nanozyme for glucose sensing.

Project description:Inspired by natural enzymes that possess multiple catalytic activities, here we develop a bifunctional metal-organic frame-work (MOF) for biosensing applications. Ultrasmall gold nano-particles (AuNPs) are grown in the internal cavities of an iron (Fe) porphyrin-based MOF to produce a hybridized nanozyme, AuNPs@PCN-224(Fe), in which AuNPs and PCN-224(Fe) exhibit the catalytic activity of glucose oxidase (GOx) and horseradish peroxidase (HRP), respectively. We established that the bifunctional nanozyme was capable of a cascade reaction to generate hydrogen peroxide in the presence of d-glucose and oxygen in situ, and subsequently activate a colorimetric or chemiluminescent substrate through HRP-mimicking catalytic activity. The nanozyme was selective over a range of other saccharides, and 93% of the catalytic activity was retained after being recycled five times.

| S-EPMC10355114 | biostudies-literature

Chitosan-capped gold nanoparticles for selective and colorimetric sensing of heparin.

Project description:In this contribution, novel chitosan-stabilized gold nanoparticles (AuNPs) were prepared by mixing chitosan with citrate-reductive AuNPs under appropriate conditions. The as-prepared chitosan-stabilized AuNPs were positively charged and highly stably dispersed in aqueous solution. They exhibited weak resonance light scattering (RLS) intensity and a wine red color. In addition, the chitosan-stabilized AuNPs were successfully utilized as novel sensitive probes for the detection of heparin for the first time. It was found that the addition of heparin induced a strong increase of RLS intensity for AuNPs and the color change from red to blue. The increase in RLS intensity and the color change of chitosan-stabilized AuNPs caused by heparin allowed the sensitive detection of heparin in the range of 0.2-60 ?M (~6.7 U/mL). The detection limit for heparin is 0.8 ?M at a signal-to-noise ratio of 3. The present sensor for heparin detection possessed a low detection limit and wide linear range. Additionally, the proposed method was also applied to the detection of heparin in biological media with satisfactory results.

| S-EPMC3782634 | biostudies-literature

Synthesis of Two Mononuclear Schiff Base Metal (M = Fe, Cu) Complexes: MOF Structure, Dye Degradation, H2O2 Sensing, and DNA Binding Property.

Project description:O-Vanillin and ethylenediamine were used for the synthesis of N,N'-bis(O-vanillinidene)ethylenediamine (O-VEDH2) Schiff base ligand, which was characterized by UV-visible and 1H NMR spectroscopy. The Schiff base ligand O-VEDH2 has been employed to synthesize novel [C18H22FeN2O6]NO3 (1) and C18H16CuN2O5 (2) complexes by the simple slow evaporation method. The single crystals were characterized by X-ray crystallography, as well as Fourier-transform infrared and UV-visible spectroscopy techniques. Complexes 1 and 2 crystallize in monoclinic and orthorhombic space groups with P121/n1 (14) and Pnma (62) point groups, respectively, and both show metal-organic frameworks like structures. Complexes 1 and 2 have optical band gaps of 4.1 and 2.9 eV, respectively, indicating their semiconducting properties. The dye degradation activity and H2O2 sensing of the complexes 1 and 2 were determined in different conditions. The photocatalytic test was performed in the presence of sunlight, methylene blue (MB), and complexes 1 and 2. An interesting result was obtained that complex 2 has degradation ability against MB and the rate constant (K) is 5.46 × 10-5 s-1, whereas complex 1 has H2O2 sensing properties. Both complexes are bound to Calf-thymus DNA by intercalation binding mode, and binding constants (K b) of complexes 1 and 2 are 3.77 × 103 and 1.49 × 104 M-1, respectively.

| S-EPMC6777120 | biostudies-literature

Stereochemical Properties of Two Schiff-Base Transition Metal Complexes and Their Ligand by Using Multiple Chiroptical Spectroscopic Tools and DFT Calculations.

Project description:Two transition metal complexes were synthesized with Ni(II) and Cu(II) using a tetradentate Schiff-base ligand, (R,R) and (S,S)-N,N'-Bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine. The stereochemical properties of the ligand and the metal complexes were investigated using a combined experimental and theoretical approach. Multiple spectroscopic techniques, which include IR, vibrational circular dichroism (VCD), UV-Vis and electronic circular dichroism (ECD), as well as Raman and the newly discovered ECD-circularly polarized Raman (i.e., eCP-Raman) spectroscopies were utilized. The good agreement achieved between the experimental and simulated IR, VCD, UV-Vis and ECD spectra of the ligand allowed one to identify the presence of three main ligand conformers in solution, thanks, especially to the high VCD sensitivity to the conformations associated with the tertbutyl groups. The helicity of the metal complexes was identified to be M and P for those with the (R,R) and (S,S) ligands, respectively. Furthermore, eCP-Raman measurements were carried out for the two metal complexes under (near) resonance. Their induced solvent chiral Raman features were explained, and the potential application of eCP-Raman was discussed.

| S-EPMC10054095 | biostudies-literature

Methionine-Capped Gold Nanoclusters as a Fluorescence-Enhanced Probe for Cadmium(II) Sensing.

Project description:Gold nanoclusters (Au NCs) have been considered as novel heavy metal ions sensors due to their ultrafine size, photo-stability and excellent fluorescent properties. In this study, a green and facile method was developed for the preparation of fluorescent water-soluble gold nanoclusters with methionine as a stabilizer. The nanoclusters emit orange fluorescence with excitation/emission peaks at 420/565 nm and a quantum yield of about 1.46%. The fluorescence of the Au NCs is selectively and sensitively enhanced by addition of Cd(II) ions attributed to the Cd(II) ion-induced aggregation of nanoclusters. This finding was further used to design a fluorometric method for the determination of Cd(II) ions, which had a linear response in the concentration range from 50 nM to 35 ?M and a detection limit of 12.25 nM. The practicality of the nanoprobe was validated in various environmental water samples and milk powder samples, with a fairly satisfactory recovery percent.

| S-EPMC5855495 | biostudies-literature

Synthesis of an amantadine-based novel Schiff base and its transition metal complexes as potential ALP, α-amylase, and α-glucosidase inhibitors.

Project description:A Schiff base ligand HL, (E)-2-((adamantan-1-ylimino)methyl)-6-allylphenol, was synthesized by condensation of amantadine with 3-allyl-2-hydroxybenzaldehyde, followed by the synthesis of its Zn(ii), Co(ii), Cr(iii), and VO(iv) complexes under reflux conditions. The synthesized compounds were comprehensively elucidated by using different spectroscopic and analytical techniques: UV-Vis, 1H and 13C-NMR, FT-IR, ESI-MS, thermal, and single-crystal XRD analysis. The chemical composition of the synthesized compounds was also verified by molar conductance and elemental analysis. An octahedral geometry for Cr(iii) and Co(ii) complexes, tetrahedral for Zn(ii) complex, and square pyramidal geometry have been proposed for VO(iv) complexes. The antidiabetic activities of the synthesized compounds were also evaluated by performing in vitro α-amylase and α-glucosidase inhibition studies. The Co(ii) complex exhibited the highest α-glucosidase inhibitory activity, whereas oxovanadium(iv) and zinc(ii) complexes were also found to be effective against α-amylase. In alkaline phosphatase (ALP) inhibition studies, the HL was found to be inactive, while the complexes showed remarkable enzyme inhibition in the following order: VO > Zn > Co, in a concentration-dependent manner.

| S-EPMC9846949 | biostudies-literature

Synthesis, characterization, Hirshfeld surface analysis, antioxidant and selective β-glucuronidase inhibitory studies of transition metal complexes of hydrazide based Schiff base ligand.

Project description:The synthesis of N'-[(4-hydroxy-3-methoxyphenyl)methylidene] 2-aminobenzohydrazide (H-AHMB) was performed by condensing O-vanillin with 2-aminobenzohydrazide and was characterized by FTIR, high resolution ESI(+) mass spectral analysis, 1H and 13C-NMR. The compound H-AHMB was crystallized in orthorhombic Pbca space group and studied for single crystal diffraction analysis. Hirshfeld surface analysis was also carried out for identifying short interatomic interactions. The major interactions H…H, O…H and C…H cover the Hirshfeld surface of H-AHMB. The metal complexes [M(AHMB)n] where M = Co(II), Ni(II), Cu(II) and Zn(II) were prepared from metal chlorides and H-AHMB ligand. The bonding was unambigously assigned using FTIR and UV/vis analysis. The synthesized ligand H-AHMB and its metal complexes were studied for β-glucuronidase enzyme inhibition. Surprisingly the metal complexes were found more active than the parent ligand and even the standard drug. Zn-AHMB shown IC50 = 17.3 ± 0.68 µM compared to IC50 = 45.75 ± 2.16 µM shown by D-saccharic acid-1,4-lactone used as standard. The better activity by Zn-AHMB implying zinc based metallodrug for the treatment of diseases associated with β-glucuronidase enzyme. The DPPH radical scavenging activities were also studied for all the synthesized compounds. The Co-AHMB complex with IC50 = 98.2 ± 1.78 µM was the only candidate to scavenge the DPPH free radicals.

| S-EPMC10766943 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data