Mechanism of action of the des-F(6) quinolone BMS-284756 measured by supercoiling inhibition and cleavable complex assays.
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SUBMITTER: Wu P
PROVIDER: S-EPMC90894 | biostudies-literature | 2001 Dec
REPOSITORIES: biostudies-literature
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Mechanism of action of the des-F(6) quinolone BMS-284756 measured by supercoiling inhibition and cleavable complex assays.
Wu P P Lawrence L E LE Denbleyker K L KL Barrett J F JF
Antimicrobial agents and chemotherapy 20011201 12
BMS-284756 (T-3811ME), a novel des-F(6) quinolone, was tested in the supercoiling inhibition and cleavable complex assays against Escherichia coli DNA gyrase, a target of quinolones. The results suggest that BMS-284756 has the same mechanism of action against DNA gyrase as other quinolones and a similar level of potency. ...[more]
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