Dataset Information

A two-sample Mendelian randomization analysis of modifiable risk factors and intracranial aneurysms.

ABSTRACT: We aimed to investigate the causality between potentially modifiable risk factors and the risk of intracranial aneurysm. Genetic instruments for 51 modifiable factors and intracranial aneurysm data were obtained from recently published genome-wide association studies. We applied two-sample Mendelian randomization methods to investigate their causal relationships. Genetically predicted cigarettes per day, smoking initiation, systolic blood pressure, hypertension and body fat percentage were significantly associated with an increased risk of intracranial aneurysm [odds ratios (OR) 2.67, 95% confidence interval (CI) 1.75-4.07, p = 5.36 × 10^-6, OR 1.53, 95% CI 1.32-1.77, p = 9.58 × 10^-9, OR 1.05, 95% CI 1.02-1.08, p = 1.18 × 10^-3, OR 1.65, 95% CI 1.19-2.28, p = 2.56 × 10^-3 and OR 1.29, 95% CI 1.11-1.52, p = 1.33 × 10^-3, respectively]. Type 2 diabetes mellitus was significantly associated with a decreased risk of intracranial aneurysm (OR 0.89, 95% CI 0.83-0.95, p = 8.54 × 10^-4). Body fat percentage was significantly associated with subarachnoid haemorrhage (p = 5.70 × 10^-5). This study provided genetic evidence of causal effects of smoking, blood pressure, type 2 diabetes mellitus and obesity on the risk of intracranial aneurysm.

SUBMITTER: Tian D

PROVIDER: S-EPMC9091241 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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A two-sample Mendelian randomization analysis of modifiable risk factors and intracranial aneurysms.

Tian Danyang D Zhang Linjing L Zhuang Zhenhuang Z Huang Tao T Fan Dongsheng D

Scientific reports 20220510 1

We aimed to investigate the causality between potentially modifiable risk factors and the risk of intracranial aneurysm. Genetic instruments for 51 modifiable factors and intracranial aneurysm data were obtained from recently published genome-wide association studies. We applied two-sample Mendelian randomization methods to investigate their causal relationships. Genetically predicted cigarettes per day, smoking initiation, systolic blood pressure, hypertension and body fat percentage were signi ...[more]

PMID: 35538134

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Project description:ObjectiveSeveral studies have explored the relationship between intracranial aneurysms and psychiatric disorders; nevertheless, the causal connection remains ambiguous. This study aimed to evaluate the causal link between intracranial aneurysms and specific psychiatric disorders.MethodsA two-sample Mendelian randomization (MR) analysis was conducted utilizing aggregated genome-wide association study (GWAS) data from the International Stroke Genetics Association for Intracranial Aneurysms (IAs), unruptured Intracranial Aneurysm (uIA), and aneurysmal Subarachnoid Hemorrhage (aSAH). Psychiatric disorder data, encompassing Schizophrenia (SCZ), Bipolar Disorder (BD), and Panic Disorder (PD), were sourced from the Psychiatric Genomics Consortium (PGC), while Cognitive Impairment (CI) data, comprising Cognitive Function (CF) and Cognitive Performance (CP), were obtained from IEU OpenGWAS publications. Causal effects were evaluated using inverse variance weighted (IVW), MR-Egger, and weighted median methods, with the robustness of findings assessed via sensitivity analyses employing diverse methodological approaches.ResultsOur MR analysis indicated no discernible causal link between intracranial aneurysm (IA) and an elevated susceptibility to psychiatric disorders. However, among individuals with genetically predisposed unruptured intracranial aneurysms (uIA), there was a modest reduction in the risk of SCZ (IVW odds ratio [OR] = 0.95, 95% confidence interval [CI] 0.92-0.98, p = 0.0002). Similarly, IAs also exhibited a moderate reduction in SCZ risk (OR = 0.92, 95% CI 0.86-0.99, p = 0.02). Nevertheless, limited evidence was found to support a causal association between intracranial aneurysms and the risk of the other three psychiatric disorders.ConclusionOur findings furnish compelling evidence suggesting a causal influence of intracranial aneurysms on psychiatric disorders, specifically, both IAs and uIA exhibit a negative causal association with SCZ.

Dataset Information

A two-sample Mendelian randomization analysis of modifiable risk factors and intracranial aneurysms.

Publications

A two-sample Mendelian randomization analysis of modifiable risk factors and intracranial aneurysms.

Similar Datasets

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