Towards identification of protein-protein interaction stabilizers via inhibitory peptide-fragment hybrids using templated fragment ligation.
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ABSTRACT:
SUBMITTER: Srdanovic S
PROVIDER: S-EPMC9092428 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
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Towards identification of protein-protein interaction stabilizers <i>via</i> inhibitory peptide-fragment hybrids using templated fragment ligation.
Srdanović Sonja S Hegedüs Zsofia Z Warriner Stuart L SL Wilson Andrew J AJ
RSC chemical biology 20220401 5
Using the <i>h</i>DMX/14-3-3 interaction, acylhydrazone-based ligand-directed fragment ligation was used to identify protein-protein interaction (PPI) inhibitory peptide-fragment hybrids. Separation of the peptide-fragment hybrids into the components yielded fragments that stabilized the <i>h</i>DMX/14-3-3 interaction. ...[more]
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