Ontology highlight
ABSTRACT:
SUBMITTER: Frenkel-Pinter M
PROVIDER: S-EPMC9095695 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Frenkel-Pinter Moran M Bouza Marcos M Fernández Facundo M FM Leman Luke J LJ Williams Loren Dean LD Hud Nicholas V NV Guzman-Martinez Aikomari A
Nature communications 20220511 1
It is widely assumed that the condensation of building blocks into oligomers and polymers was important in the origins of life. High activation energies, unfavorable thermodynamics and side reactions are bottlenecks for abiotic peptide formation. All abiotic reactions reported thus far for peptide bond formation via thioester intermediates have relied on high energy molecules, which usually suffer from short half-life in aqueous conditions and therefore require constant replenishment. Here we re ...[more]