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Efficient preparation of unsymmetrical disulfides by nickel-catalyzed reductive coupling strategy.

ABSTRACT: Disulfides are widely found in natural products and find a wide range of applications in life sciences, materials chemistry and other fields. The preparation of disulfides mainly rely on oxidative couplings of two sulfur containing compounds. This strategy has many side reactions and other shortcomings. Herein, we describe the reductive nickel-catalyzed cross-electrophile coupling of unactivated alkyl bromides with symmetrical alkyl- and aryltetrasulfides to form alkyl-alkyl and aryl-alkyl unsymmetrical disulfides. This approach for disulfide synthesis is practical, relies on easily available, unfunctionalized substrates, and is scalable. We investigated the mechanism of this transformation and found that the tetrasulfide compound does not selectively break the central S-S bond, but regio-selectively generates trisulfide intermediates.

SUBMITTER: Wang F

PROVIDER: S-EPMC9095708 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Efficient preparation of unsymmetrical disulfides by nickel-catalyzed reductive coupling strategy.

Wang Fei F Chen Ying Y Rao Weidong W Ackermann Lutz L Wang Shun-Yi SY

Nature communications 20220511 1

Disulfides are widely found in natural products and find a wide range of applications in life sciences, materials chemistry and other fields. The preparation of disulfides mainly rely on oxidative couplings of two sulfur containing compounds. This strategy has many side reactions and other shortcomings. Herein, we describe the reductive nickel-catalyzed cross-electrophile coupling of unactivated alkyl bromides with symmetrical alkyl- and aryltetrasulfides to form alkyl-alkyl and aryl-alkyl unsym ...[more]

PMID: 35546155

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