Ontology highlight
ABSTRACT:
SUBMITTER: Fang L
PROVIDER: S-EPMC9097848 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Fang Lian L Feng Rui R Liang Weiye W Liu Fang-Fang FF Bian Gan-Lan GL Yu Caiyong C Guo Hongmin H Cao Yihui Y Liu Mingkai M Zuo Jia J Peng Yinglong Y Zhao Jie J Sun Rui-Xia RX Shan Jiajie J Wang Jian J
Journal of cellular and molecular medicine 20220405 10
Spermatogenesis is a cyclical process in which different generations of spermatids undergo a series of developmental steps at a fixed time and finally produce spermatids. Here, we report that overexpression of PD-L1 (B7 homolog1) in the testis causes sperm developmental disorders and infertility in male mice, with severe malformation and sloughing during spermatid development, characterized by disorganized and collapsed seminiferous epithelium structure. PD-L1 needs to be simultaneously expresse ...[more]