Ontology highlight
ABSTRACT:
SUBMITTER: Kurtanovic N
PROVIDER: S-EPMC9101642 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20220428 9
The estrogen receptor α (ERα) is an important biological target mediating 17β-estradiol driven breast cancer (BC) development. Aiming to develop innovative drugs against BC, either wild-type or mutated ligand-ERα complexes were used as source data to build structure-based 3-D pharmacophore and 3-D QSAR models, afterward used as tools for the virtual screening of National Cancer Institute datasets and hit-to-lead optimization. The procedure identified Brefeldin A (<b>BFA</b>) as hit, then structu ...[more]