Unknown

Dataset Information

0

Serum Leucine-Rich Alpha-2 Glycoprotein in Quiescent Crohn's Disease as a Potential Surrogate Marker for Small-Bowel Ulceration detected by Capsule Endoscopy.


ABSTRACT:

Background

Small bowel (SB) lesions in quiescent Crohn's disease (CD) are sometimes not identified by clinical activity or existing markers. We investigated the usefulness of a novel biomarker, leucine-rich α2-glycoprotein (LRG), for screening for the presence of SB ulcerative lesions detected by small-bowel capsule endoscopy (SBCE).

Methods

We examined patients with a Crohn's Disease Activity Index (CDAI) value < 150 and a C-reactive protein (CRP) value < 0.5 mg/dL with SB or SB colonic CD. The presence of small-bowel ulcerative lesions (≥0.5 cm) was grouped by SBCE results, and we then compared the groups' LRG value to establish a cutoff value for screening for the presence of lesions.

Results

In 40 patients with CD, the LRG values differed significantly between the patients with and without SB ulcerative lesions (Ul + 14.1 (2.1-16.5) μg/mL vs. Ul - 12.3 (9.3-13.5) μg/mL; p = 0.0105). The respective cutoff LRG values for the presence of SB ulcerative lesions was 14 μg/mL (areas under the ROC curve 0.77), with sensitivity 63.6%, specificity 82.8%, positive predictive values 58.3%, negative predictive values 85.7%, and accuracy 78%.

Conclusion

These results indicate that LRG may be useful in predicting the presence of SB inflammation associated in patients with CD with CRP < 0.5 mg/dL and CDAI < 150, and in selecting patients for SBCE.

SUBMITTER: Omori T 

PROVIDER: S-EPMC9101788 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Serum Leucine-Rich Alpha-2 Glycoprotein in Quiescent Crohn's Disease as a Potential Surrogate Marker for Small-Bowel Ulceration detected by Capsule Endoscopy.

Omori Teppei T   Sasaki Yu Y   Koroku Miki M   Murasugi Shun S   Yonezawa Maria M   Nakamura Shinichi S   Tokushige Katsutoshi K  

Journal of clinical medicine 20220429 9


Background: Small bowel (SB) lesions in quiescent Crohn’s disease (CD) are sometimes not identified by clinical activity or existing markers. We investigated the usefulness of a novel biomarker, leucine-rich α2-glycoprotein (LRG), for screening for the presence of SB ulcerative lesions detected by small-bowel capsule endoscopy (SBCE). Methods: We examined patients with a Crohn’s Disease Activity Index (CDAI) value < 150 and a C-reactive protein (CRP) value < 0.5 mg/dL with SB or SB colonic CD. T  ...[more]

Similar Datasets

| S-EPMC9955912 | biostudies-literature
| S-EPMC11534453 | biostudies-literature
| S-EPMC11249762 | biostudies-literature
| S-EPMC7678730 | biostudies-literature
| S-EPMC1774425 | biostudies-literature
| S-EPMC10333642 | biostudies-literature
| S-EPMC5398361 | biostudies-literature
| S-EPMC4984327 | biostudies-literature
| S-EPMC9802189 | biostudies-literature
| S-EPMC6231365 | biostudies-literature