SARS-CoV-2 variant trends in Ireland: Wastewater-based epidemiology and clinical surveillance.

ABSTRACT: SARS-CoV-2 RNA quantification in wastewater is an important tool for monitoring the prevalence of COVID-19 disease on a community scale which complements case-based surveillance systems. As novel variants of concern (VOCs) emerge there is also a need to identify the primary circulating variants in a community, accomplished to date by sequencing clinical samples. Quantifying variants in wastewater offers a cost-effective means to augment these sequencing efforts. In this study, SARS-CoV-2 N1 RNA concentrations and daily loadings were determined and compared to case-based data collected as part of a national surveillance programme to determine the validity of wastewater surveillance to monitor infection spread in the greater Dublin area. Further, sequencing of clinical samples was conducted

SUBMITTER: Reynolds LJ 

PROVIDER: S-EPMC9110007 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature