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White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation.

ABSTRACT: It is well known that white blood cell (WBC) count is an independent predictor of cardiovascular events. However, associations of WBC count and WBC subtypes with endothelial function assessed by flow-mediated vasodilation (FMD) and vascular smooth muscle function assessed by nitroglycerine-induced vasodilation (NID) are unclear. The aim of this study was to determine the relationships of WBC count and WBC subtypes with vascular function assessed by FMD and NID. A total of 1351 subjects in whom FMD and NID had been measured were recruited from Hiroshima University Vascular Registry. Mean values were 3.7 ± 2.8% for FMD and 11.8 ± 5.9% for NID. WBC was not correlated with FMD or NID. NID was significantly correlated with lymphocytes in univariate analysis but not with other hematologic parameters. In multiple linear regression analyses, NID was not correlated with lymphocytes. In all subgroups including subgroups of age, gender, body mass index, hypertension, dyslipidemia, diabetes mellitus, smoking and tertile of WBC count, WBC count was not correlated with FMD or NID. WBC count and WBC subtypes were not associated with endothelial function assessed by FMD or vascular smooth muscle function assessed by NID. WBC count and vascular function assessed by FMD and NID may reflect different aspects of atherosclerosis.Clinical Trial Registration Information: URL for Clinical Trial: http://www.umin.ac.jp Registration Number for Clinical Trial: UMIN000039512.

SUBMITTER: Kishimoto S

PROVIDER: S-EPMC9114000 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation.

Kishimoto Shinji S Maruhashi Tatsuya T Kajikawa Masato M Harada Takahiro T Yamaji Takayuki T Han Yiming Y Mizobuchi Aya A Hashimoto Yu Y Yoshimura Kenichi K Nakano Yukiko Y Chayama Kazuaki K Goto Chikara C Yusoff Farina Mohamad FM Nakashima Ayumu A Higashi Yukihito Y

Scientific reports 20220517 1

It is well known that white blood cell (WBC) count is an independent predictor of cardiovascular events. However, associations of WBC count and WBC subtypes with endothelial function assessed by flow-mediated vasodilation (FMD) and vascular smooth muscle function assessed by nitroglycerine-induced vasodilation (NID) are unclear. The aim of this study was to determine the relationships of WBC count and WBC subtypes with vascular function assessed by FMD and NID. A total of 1351 subjects in whom F ...[more]

PMID: 35581258

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Project description:First-degree atrioventricular block (AVB) is a common electrocardiogram finding in clinical practice. Vascular dysfunction is associated with cardiovascular disease and events. There is no information on the association of AVB with vascular function. The purpose of this study was to evaluate the associations of PR interval with vascular function assessed in well-characterized subjects. A total of 2220 subjects were enrolled in this study. We evaluated endothelium-dependent vasodilatation assessed by flow-mediated vasodilation (FMD) and endothelium-independent vasodilatation assessed by nitroglycerine-induced vasodilation (NID) in 106 subjects with first-degree AVB (70 men; mean age, 64.3 ± 12.9 years) and 1241 subjects with normal PR interval (531 men; mean age, 56.1 ± 13.9 years). Subjects with first-degree AVB had a lower FMD value than that in subjects with normal PR interval (3.5 ± 2.4% vs. 4.9 ± 3.3%, P < 0.001). FMD was significantly lower in subjects with first-degree AVB than in subjects with normal PR interval even after adjustment of confounding factors for assessment of endothelium-dependent vasodilatation (OR: 1.73, 95% CI: 1.11-2.70; P = 0.015). Although NID was significantly lower in subjects with first-degree AVB than in subjects with normal PR interval (11.1 ± 6.0% vs. 13.6 ± 6.1%, P < 0.001), there was no significant difference in NID between the two groups in multivariate analysis (OR: 1.48, 95% CI: 0.91-2.41; P = 0.117). Both endothelium-dependent and endothelium-independent vasodilation in the brachial artery are impaired in parallel with the prolongation of atrioventricular conduction. After adjustments of confounding factors for vascular function, first-degree AVB is associated with impaired endothelium-dependent vasodilatation but not with impaired endothelium-independent vasodilatation. From the aspect of vascular function, it is unlikely that first-degree AVB is an electrocardiography abnormality with a good prognosis.

Project description:This study examines the prognostic impact of C-reactive protein (CRP) and white blood cell (WBC) counts in patients with cardiogenic shock (CS). Data regarding the prognostic impact of inflammatory biomarkers in CS are scarce. All consecutive patients with CS from 2019 to 2021 admitted to a cardiac intensive care unit (ICU) were included at one institution. Laboratory measurements were retrieved from the day of admission (i.e., day 1), as well as days 2, 3, 4, and 8. The primary endpoint was 30-day all-cause mortality. Statistical analyses included univariate t-tests, Spearman's correlations, C-statistics, Kaplan-Meier, and Cox regression analyses. From a total of 240 consecutive patients admitted with CS, 55% died within 30 days. CRP levels on days 3 to 8 were associated with reliable discrimination for 30-day all-cause mortality (area under the curve (AUC): 0.623-0.754), whereas CRP on day 1 was not (AUC = 0.514). In line, CRP > 100 mg/L on day 3 (56% vs. 37%; log-rank p = 0.023; HR = 1.702; 95% CI 1.060-2.735; p = 0.028) and especially a CRP increase of at least 200% from days 1 to day 3 (51% vs. 35%; log-rank p = 0.040; HR = 1.720; 95% CI 1.006-2.943; p = 0.048) were associated with an increased risk of all-cause mortality. Furthermore, WBC on day 1 discriminated 30-day all-cause mortality (AUC = 0.605; p = 0.005) with an increased risk of all-cause mortality in patients admitted with WBC > 10 × 106/mL (59% vs. 40%; log-rank p = 0.036; HR = 1.643; 95% CI 1.010-2.671; p = 0.045). In conclusion, WBC count on admission as well as CRP levels during the course of ICU treatment were associated with 30-day all-cause mortality. Specifically, an increase of CRP levels by at least 200% from day 1 to day 3 during the course of ICU treatment was associated with an increased risk of 30-day all-cause mortality. The present study is one of the first to describe the prognostic value of inflammatory biomarkers in consecutive all-comer CS patients treated at a cardiac ICU.

Dataset Information

White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation.

Publications

White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation.

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