Ontology highlight
ABSTRACT:
SUBMITTER: Hatta M
PROVIDER: S-EPMC9118137 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Hatta Masahiko M Kaibori Masaki M Matsushima Hideyuki H Yoshida Terufumi T Okumura Tadayoshi T Hayashi Mikio M Yoshii Kengo K Todo Tomoki T Sekimoto Mitsugu M
Molecular therapy oncolytics 20220426
Malignant soft tissue tumors, particularly highly malignant leiomyosarcomas, are resistant to chemotherapy and associated with a poor prognosis. T-01, a third-generation genetically modified herpes simplex virus type 1, replicates in tumor cells alone and exerts a cell-killing effect. The current study aimed to investigate the antitumor effect of T-01, which is a novel treatment for leiomyosarcoma. <i>In vitro</i>, six human cell lines and one mouse sarcoma cell line were assessed for T-01 cytot ...[more]