Dataset Information

Female genital tuberculosis presented with primary infertility and persistent CA-125 elevation: A case report.

ABSTRACT:

Introduction

and importance: Tuberculosis is one of the leading causes of mortality in many developing countries. Female genital tuberculosis, a relatively uncommon form of tuberculosis, is critically challenging to diagnose due to its insidious and non-typical presentations.

Case presentation

Herein, we present with an asymptomatic infertile woman with persistently high CA-125 passed undiagnosed until laparoscopy unveiled the diagnosis of TB.

Clinical discussion

In this study, we highlight the diagnostic complexities in female genital tuberculosis and demonstrate the value of the CA-125 increase in prompting the suspicion of tuberculosis in the appropriate clinical context.

Conclusion

Given the considerably large number of individuals with tuberculosis in China, we strongly recommend routine tuberculosis screening in women seeking infertility care in China.

SUBMITTER: Feng Q

PROVIDER: S-EPMC9118513 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Female genital tuberculosis presented with primary infertility and persistent CA-125 elevation: A case report.

Feng Qian Q Hu Xiaoxia X Zhao Jing J Huang Jingyao J Liu Liling L

Annals of medicine and surgery (2012) 20220503

<h4>Introduction</h4>and importance: Tuberculosis is one of the leading causes of mortality in many developing countries. Female genital tuberculosis, a relatively uncommon form of tuberculosis, is critically challenging to diagnose due to its insidious and non-typical presentations.<h4>Case presentation</h4>Herein, we present with an asymptomatic infertile woman with persistently high CA-125 passed undiagnosed until laparoscopy unveiled the diagnosis of TB.<h4>Clinical discussion</h4>In this st ...[more]

PMID: 35600189

Similar Datasets

Project description:Various studies have shown Staphylococcus aureus to be one of the most prevalent organism in male and female genital tract but most practitioners dismiss it as mere contamination which is assumed to be of no significance. However, it is now suggested that the presence of this organism should not be ignored, as incubation of spermatozoa with S. aureus results in reduced sperm motility. Although S. aureus has been reported to cause immobilization of spermatozoa, however, its role in infertility has yet to be elucidated. The present study was designed to establish a spermagglutinating strain of S. aureus isolated from the cervix of a woman with unexplained infertility, in mouse and evaluate its effect on fertility outcome. Female Balb/c mice were inoculated intravaginally with different doses of S. aureus (10(4), 10(6) or 10(8)cfu/20 µl) for 10 consecutive days. Microbial colonization monitored every 3(rd) day by vaginal cultures, revealed that strain could efficiently colonize mouse vagina. Mating on day 12, with proven breeder males led to 100% decrease in fertility as compared to control. Even a single dose of 10(6) or 10(8)cfu could lead to vaginal colonization which persisted for 10 days followed by gradual clearing till 21 days, vaginal cultures were negative thereafter. Female mice mated on day 7 (culture positive), were rendered infertile, however, the mice mated on day 22 (culture negative), retained fertility and delivered pups indicating its role in provoking infertility. Further, except infertility, no other clinical manifestation could be seen apparently or histologically. However, when a non-spermagglutinating/immobilizing standard strain of S. aureus MTCC6625 was inoculated intravaginally at 10(8)cfu for 10 days followed by mating on day 12, fertility was observed in all the female mice. This supports the hypothesis that infertility observed in the former groups was as a result of colonization with spermagglutinating strain of S. aureus.

Dataset Information

Female genital tuberculosis presented with primary infertility and persistent CA-125 elevation: A case report.

Introduction

Case presentation

Clinical discussion

Conclusion

Publications

Female genital tuberculosis presented with primary infertility and persistent CA-125 elevation: A case report.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets