Ontology highlight
ABSTRACT:
SUBMITTER: Trumpff C
PROVIDER: S-EPMC9118667 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Trumpff Caroline C Owusu-Ansah Edward E Klein Hans-Ulrich HU Lee Annie J AJ Petyuk Vladislav V Wingo Thomas S TS Wingo Aliza P AP Thambisetty Madhav M Ferrucci Luigi L Seyfried Nicholas T NT Bennett David A DA De Jager Philip L PL Picard Martin M
Heliyon 20220430 5
Mitochondrial respiratory chain (RC) function requires the stoichiometric interaction among dozens of proteins but their co-regulation has not been defined in the human brain. Here, using quantitative proteomics across three independent cohorts we systematically characterized the co-regulation patterns of mitochondrial RC proteins in the human dorsolateral prefrontal cortex (DLPFC). Whereas the abundance of RC protein subunits that physically assemble into stable complexes were correlated, indic ...[more]