A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway.
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ABSTRACT:
SUBMITTER: Parikh BH
PROVIDER: S-EPMC9119969 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway.
Parikh Bhav Harshad BH Liu Zengping Z Blakeley Paul P Lin Qianyu Q Singh Malay M Ong Jun Yi JY Ho Kim Han KH Lai Joel Weijia JW Bogireddi Hanumakumar H Tran Kim Chi KC Lim Jason Y C JYC Xue Kun K Al-Mubaarak Abdurrahmaan A Yang Binxia B R Sowmiya S Regha Kakkad K Wong Daniel Soo Lin DSL Tan Queenie Shu Woon QSW Zhang Zhongxing Z Jeyasekharan Anand D AD Barathi Veluchamy Amutha VA Yu Weimiao W Cheong Kang Hao KH Blenkinsop Timothy A TA Hunziker Walter W Lingam Gopal G Loh Xian Jun XJ Su Xinyi X
Nature communications 20220519 1
One common cause of vision loss after retinal detachment surgery is the formation of proliferative and contractile fibrocellular membranes. This aberrant wound healing process is mediated by epithelial-mesenchymal transition (EMT) and hyper-proliferation of retinal pigment epithelial (RPE) cells. Current treatment relies primarily on surgical removal of these membranes. Here, we demonstrate that a bio-functional polymer by itself is able to prevent retinal scarring in an experimental rabbit mode ...[more]
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