HLA-DQ heterodimers in hematopoietic cell transplantation.
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ABSTRACT:
SUBMITTER: Petersdorf EW
PROVIDER: S-EPMC9121842 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
HLA-DQ heterodimers in hematopoietic cell transplantation.
Petersdorf Effie W EW Bengtsson Mats M Horowitz Mary M McKallor Caroline C Spellman Stephen R SR Spierings Eric E Gooley Ted A TA Stevenson Phil P
Blood 20220501 20
HLA-DQ heterodimers increase the susceptibility to autoimmune diseases, but their role in hematopoietic cell transplantation is unknown. We tested the hypothesis that outcome after HLA-matched and HLA-DQ-mismatched hematopoietic cell transplantation is influenced by HLA-DQ heterodimers. Heterodimers were defined in 5164 HLA-matched and 520 HLA-DQ-mismatched patients and their transplant donors according to well-established crystallographic criteria. Group 1 (G1) heterodimers are any DQA1*02/03/0 ...[more]
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