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ABSTRACT: Objective
Determine whether blanket temperatures during therapeutic hypothermia (TH) are associated with 18-22 month outcomes for infants with hypoxic ischemic encephalopathy (HIE).Study design
Retrospective cohort study of 181 infants with HIE who received TH in two randomized trials within the Neonatal Research Network. We defined summative blanket temperature constructs and evaluated for association with a primary composite outcome of death or moderate/ severe disability at 18-22 months.Results
Each 0.5 °C above 33.5 °C in the mean of the highest quartile blanket temperature was associated with a 52% increase in the adjusted odds of death/ disability (aOR 1.52, 95% CI 1.09-2.11). Having >8 consecutive blanket temperatures above 33.5 °C rendered an aOR of death/disability of 5.04 in the first 24 h (95% CI 1.54-16.6) and 6.92 in the first 48 h (95% CI 2.20-21.8) of TH.Conclusions
Higher blanket temperature during TH may be an early, clinically useful biomarker of HIE outcome.
SUBMITTER: Flibotte J
PROVIDER: S-EPMC9121861 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Flibotte John J Laptook Abbot R AR Shankaran Seetha S McDonald Scott A SA Baserga Mariana C MC Bell Edward F EF Cotten C Michael CM Das Abhik A DeMauro Sara B SB DuPont Tara L TL Eichenwald Eric C EC Heyne Roy R Jensen Erik A EA Van Meurs Krisa P KP Dysart Kevin K
Journal of perinatology : official journal of the California Perinatal Association 20220108 3
<h4>Objective</h4>Determine whether blanket temperatures during therapeutic hypothermia (TH) are associated with 18-22 month outcomes for infants with hypoxic ischemic encephalopathy (HIE).<h4>Study design</h4>Retrospective cohort study of 181 infants with HIE who received TH in two randomized trials within the Neonatal Research Network. We defined summative blanket temperature constructs and evaluated for association with a primary composite outcome of death or moderate/ severe disability at 18 ...[more]