Diverse functions associate with non-coding polymorphisms shared between humans and chimpanzees.

ABSTRACT:

Background

Long-term balancing selection (LTBS) can maintain allelic variation at a locus over millions of years and through speciation events. Variants shared between species in the state of identity-by-descent, hereafter "trans-species polymorphisms", can result from LTBS, often due to host-pathogen interactions. For instance, the major histocompatibility complex (MHC) locus contains TSPs present across primates. Several hundred candidate LTBS regions have been identified in humans and chimpanzees; however, because many are in non-protein-coding regions of the genome, the functions and potential adaptive roles for most remain unknown.

Results

We integrated diverse genomic annotations to explore the functions of 60 previously identified regions with multiple shared polymorp

SUBMITTER: Velazquez-Arcelay K 

PROVIDER: S-EPMC9125839 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature