Ontology highlight
ABSTRACT:
SUBMITTER: Wu CY
PROVIDER: S-EPMC9127226 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Wu Chi-Yun CY Lau Billy T BT Kim Heon Seok HS Sathe Anuja A Grimes Susan M SM Ji Hanlee P HP Zhang Nancy R NR
Nature biotechnology 20210520 10
Cancer progression is driven by both somatic copy number aberrations (CNAs) and chromatin remodeling, yet little is known about the interplay between these two classes of events in shaping the clonal diversity of cancers. We present Alleloscope, a method for allele-specific copy number estimation that can be applied to single-cell DNA- and/or transposase-accessible chromatin-sequencing (scDNA-seq, ATAC-seq) data, enabling combined analysis of allele-specific copy number and chromatin accessibili ...[more]