TDP-43 Accumulation Within Intramuscular Nerve Bundles of Patients With Amyotrophic Lateral Sclerosis.

ABSTRACT:

Importance

Degeneration of neuromuscular junctions and axons is considered an important aspect of the pathomechanism of amyotrophic lateral sclerosis (ALS). However, a mechanism including the role of transactive response DNA-binding protein 43 (TDP-43) in axons has not been pathologically clarified.

Objective

To identify and characterize the histopathology of peripheral axons in the skeletal muscle of patients with ALS.

Design, setting, and participants

This study comprised 2 parts: a postmortem case-control study and a retrospective population-based cohort study with a minimum of 1 year of follow-up. Patients in the cohort study were enrolled from January 1, 2004, to September 30, 2019. The postmortem study included patients with sporadic ALS (SALS) with TDP-43 patho

SUBMITTER: Kurashige T 

PROVIDER: S-EPMC9127711 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature