Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Z
PROVIDER: S-EPMC9130207 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Zhou Zhaohui Z Xiong Longbin L Wu Zeshen Z Jiang Lijuan L Li Yonghong Y Li Zhiyong Z Peng Yulu Y Ning Kang K Zou Xiangpeng X Liu Zefu Z Wang Jun J Li Zhen Z Zhou Fangjian F Liu Zhuowei Z Zhang Zhiling Z Yu Chunping C
Cell death & disease 20220524 5
Multidrug resistance gene 1 (MDR1), a key factor contributing to drug insensitivity, has been associated with treatment failure and poor prognoses in various cancers, including bladder urothelial carcinoma (UC). Here we show that positive Nkx2.8 expression was associated with better prognosis of UC patients received chemotherapy. Patients with positive Nkx2.8 expression had promising prognosis from adjuvant chemotherapy. Enforced expression of Nkx2.8 promotes drug sensitivity of UC cells. Mechan ...[more]