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Progress in osteoarthritis research by the National Natural Science Foundation of China.

ABSTRACT: Osteoarthritis (OA) in China is gradually becoming an important scientific research area that has had a significant impact on research and development (R&D) activities in the OA field worldwide. This article summarizes the R&D progress related to OA in China in recent years. The National Natural Science Foundation of China (NSFC) is a national funding institution for basic research and plays a critical role in promoting and supporting Chinese scholars' R&D activities. We collected and analyzed information on NSFC funding in the field of OA from 2010 to 2019, including the amount, the level and the program categories of the funded projects. The data fully demonstrate the important and positive role of the NSFC in supporting free exploration, cultivating research teams and young talent, and boosting OA R&D. In this article, we outline and discuss hot topics in focused areas, key advances in this field and the prospects for progress in OA research in China.

SUBMITTER: Li Y

PROVIDER: S-EPMC9130253 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Progress in osteoarthritis research by the National Natural Science Foundation of China.

Li Yusheng Y Xie Wenqing W Xiao Wenfeng W Dou Dou D

Bone research 20220524 1

Osteoarthritis (OA) in China is gradually becoming an important scientific research area that has had a significant impact on research and development (R&D) activities in the OA field worldwide. This article summarizes the R&D progress related to OA in China in recent years. The National Natural Science Foundation of China (NSFC) is a national funding institution for basic research and plays a critical role in promoting and supporting Chinese scholars' R&D activities. We collected and analyzed i ...[more]

PMID: 35610209

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Project description:BackgroundThis study aimed to summarize the current situation and deficiencies of the fundamental research on pediatric otolaryngology-head and neck science. It is hoped that the results can provide support for the long-term development of the basic research on this subject.MethodsInformation concerning the applications to and funding from the National Natural Science Foundation of China (NSFC) for otolaryngology-head and neck from 2009 to 2019 was collected and analyzed.ResultsIn the past 10 years, pediatric otolaryngology-head and neck science received 150 applications, accounting for 2.92% of all applications for otolaryngology-head and neck science. Ultimately, 20 projects were funded, accounting for 2.17% of all the funded projects. There were 88 applications for children's ear science and hearing-related research, accounting for 58.67% of the applications for pediatric otolaryngology-head and neck science. Furthermore, 14 approved grants focused on cochlear implants and the genetics and mechanisms of deafness. There were 25 applications related to children's nasal science, particularly allergic rhinitis, accounting for 16.67% of the total applications. Of these, 4 applications were funded, and these mainly focused on the disease regulation and pathogenesis of allergic rhinitis. A total of 30 applications related to children's laryngopharyngeal diseases, accounting for 20% of the applications, mainly focused on obstructive sleep apnea syndrome (OSAS), adenoid hypertrophy, and tonsil hypertrophy, with only 1 application being funded. The scientific research on children's head and neck was mainly related to laryngeal papilloma and lymphatic vascular malformation, with 7 projects being applied for and 2 being funded.ConclusionsThe fundamental research of pediatric otolaryngology-head and neck science in China is at a relatively weak level and lags behind the average level of the discipline. There are relatively few basic researchers engaged in pediatric otolaryngology-head and neck science, and the dominant research units are relatively concentrated. The basic research of children's ear science is relatively advanced in each subspecialty, so the basic research on children's unique congenital and hereditary diseases should be further strengthened.

Project description:Extranodal natural killer (NK)/T-cell lymphoma, nasal type (NNKTL) has very unique epidemiological, etiologic, histologic, and clinical characteristics. It is commonly observed in Eastern Asia, but quite rare in the United States and Europe. The progressive necrotic lesions mainly in the nasal cavity, poor prognosis caused by rapid local progression with distant metastases, and angiocentric and polymorphous lymphoreticular infiltrates are the main clinical and histologic features. Phenotypic and genotypic studies revealed that the lymphoma is originated from either NK- or γδ T-cell, both of which express CD56. In 1990, the authors first reported the presence of Epstein-Barr virus (EBV)-DNA and EBV-oncogenic proteins, and EBV has now been recognized to play an etiological role in NNKTL. in vitro studies revealed that a wide variety of cytokines, chemokines, and micro RNAs, which may be produced by EBV-oncogenic proteins in the lymphoma cells, play important roles for tumor progression in NNKTL, and could be therapeutic targets. In addition, it was revealed that the interaction between NNKTL cells and immune cells such as monocytes and macrophages in NNKTL tissues contribute to lymphoma progression. For diagnosis, monitoring the clinical course and predicting prognosis, the measurements of EBV-DNAs and EBV-micro RNAs in sera are very useful. For treatment with early stage, novel concomitant chemoradiotherapy such as DeVIC regimen with local radiotherapy and MPVIC-P regimen using intra-arterial infusion developed with concomitant radiotherapy and the prognosis became noticeably better. However, the prognosis of patients with advanced stage was still poor. Establishment of novel treatments such as the usage of immune checkpoint inhibitor or peptide vaccine with molecular targeting therapy will be necessary. This review addresses recent advances in the molecular understanding of NNKTL to establish novel treatments, in addition to the epidemiologic, clinical, pathological, and EBV features.

Dataset Information

Progress in osteoarthritis research by the National Natural Science Foundation of China.

Publications

Progress in osteoarthritis research by the National Natural Science Foundation of China.

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