Association of Sleep With Risk of Alzheimer's Disease Mortality: NIH-AARP Diet and Health Study.
Ontology highlight
ABSTRACT: Objectives
Alzheimer's disease (AD) and related dementias contribute to one in three senior deaths. Lifestyle factors, including sleep, may contribute to AD risk and mortality; however, current evidence on sleep and AD mortality is mixed.Methods
We used data from the NIH-AARP Diet and Health Study. Sleep duration and napping were self-reported and AD death were ascertained via linkage to the National Death Index.Results
Long sleep and napping were both associated with increased AD mortality. Specifically, 9+ hr of sleep was associated with 50% increase (hazard ratio = 1.50, 95% CI = [1.17, 1.92]) in AD mortality when compared 7 to 8 hr, while napping for 1+ hr was associated with 29% increase (1.29 [1.08, 1.55]) when compared with no napping. Results appeared to be stronger in men and remained after removing AD deaths within first 5 years after baseline.Discussion
Long sleep and napping may predict higher AD mortality in the older population.
SUBMITTER: Schneider AC
PROVIDER: S-EPMC9131728 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Publications
Association of Sleep With Risk of Alzheimer's Disease Mortality: NIH-AARP Diet and Health Study.
Schneider Aaron C AC Moon Chooza C Whitaker Kara K Zhang Dong D Carr Lucas J LJ Bao Wei W Xiao Qian Q
Journal of applied gerontology : the official journal of the Southern Gerontological Society 20210610 4
<h4>Objectives</h4>Alzheimer's disease (AD) and related dementias contribute to one in three senior deaths. Lifestyle factors, including sleep, may contribute to AD risk and mortality; however, current evidence on sleep and AD mortality is mixed.<h4>Methods</h4>We used data from the NIH-AARP Diet and Health Study. Sleep duration and napping were self-reported and AD death were ascertained via linkage to the National Death Index.<h4>Results</h4>Long sleep and napping were both associated with inc ...[more]
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