Ontology highlight
ABSTRACT:
SUBMITTER: Clain J
PROVIDER: S-EPMC9139333 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Clain Julien J Couret David D Planesse Cynthia C Krejbich-Trotot Pascale P Meilhac Olivier O Lefebvre d'Hellencourt Christian C Viranaicken Wildriss W Diotel Nicolas N
Brain sciences 20220523 5
Adiponectin exhibits pleiotropic effects, including anti-inflammatory, anti-apoptotic, anti-oxidant, and neuroprotective ones. Although some studies have documented brain expression in different rodent models of its receptors, AdipoR1 and AdipoR2, their global distribution remains incomplete. Here, we demonstrated that both AdipoR are widely distributed in the brains of adult mice. Furthermore, by double immunostaining studies, we showed that AdipoR1 and AdipoR2 are mainly expressed in neurons a ...[more]