Ontology highlight
ABSTRACT: Background
Salivary cortisol (SC), a commonly used biomarker for stress, may be disrupted by negative events in pregnancy, at birth and in infancy. We aimed to explore if maternal perceived stress (PSS) in or after pregnancy and SC levels in pregnancy were associated with SC in early infancy, and, secondly, to identify early life factors associated with infants' SC levels (iSC).Methods
At 3 months of age, SC was analyzed in 1057 infants participating in a Nordic prospective mother-child birth cohort study. Maternal PSS was available from questionnaires at 18- and 34-week gestational age (GA) and 3-month post-partum, and SC was analyzed at 18-week GA. Early life factors included sociodemographic and infant feeding from questionnaires, and birth data from medical charts. Associations to iSC were analyzed by Spearman correlation and multinomial logistic regression analyses.Results
In this exploratory study neither PSS at any time point nor maternal SC (mSC) were associated with iSC. Higher birth weight was associated with higher levels of iSC, while inverse associations were observed in infants to a mother not living with a partner and mixed bottle/breastfeeding.Conclusions
Maternal stress was not associated with iSC levels, while birth weight, single motherhood and infant feeding may influence iSC levels.
SUBMITTER: Olsson Magi CA
PROVIDER: S-EPMC9139396 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Olsson Mägi Caroline-Aleksi CA Wik Despriee Åshild Å Småstuen Milada Cvancarova MC Almqvist Catarina C Bahram Fuad F Bakkeheim Egil E Bjerg Anders A Glavin Kari K Granum Berit B Haugen Guttorm G Hedlin Gunilla G Jonassen Christine Monceyron CM Lødrup Carlsen Karin C KC Rehbinder Eva Maria EM Rolfsjord Leif-Bjarte LB Staff Anne Cathrine AC Skjerven Håvard Ove HO Vettukattil Riyas R Nordlund Björn B Söderhäll Cilla C
Children (Basel, Switzerland) 20220427 5
<h4>Background</h4>Salivary cortisol (SC), a commonly used biomarker for stress, may be disrupted by negative events in pregnancy, at birth and in infancy. We aimed to explore if maternal perceived stress (PSS) in or after pregnancy and SC levels in pregnancy were associated with SC in early infancy, and, secondly, to identify early life factors associated with infants' SC levels (iSC).<h4>Methods</h4>At 3 months of age, SC was analyzed in 1057 infants participating in a Nordic prospective mothe ...[more]