Dataset Information

Quantitative Sodium (²³Na) MRI in Pediatric Gliomas: Initial Experience.

ABSTRACT:

Background

²³Na MRI correlates with tumor proliferation, and studies in pediatric patients are lacking.

The purpose of the study

(1) to compare total sodium concentration (TSC) between pediatric glioma and non-neoplastic brain tissue using ²³Na MRI; (2) compare tissue conspicuity of bound sodium concentration (BSC) using ²³Na MRI dual echo relative to TSC imaging.

Methods

TSC was measured in: (1) non-neoplastic brain tissues and (2) three types of manually segmented gliomas (diffuse intrinsic brainstem glioma (DIPG), recurrent supratentorial low-grade glioma (LGG), and high-grade glioma (HGG)). In a subset of patients, serial changes in both TSC and BSC (dual echo ²³Na MRI) were assessed.

Results

Twenty-six pediatric patients with gliomas (median age of 12.0 years, range 4.9-23.3 years) were scanned with ²³Na MRI. DIPG treated with RT demonstrated higher TSC values than the uninvolved infratentorial tissues (p < 0.001). Recurrent supratentorial LGG and HGG exhibited higher TSC values than the uninvolved white matter (WM) and gray matter (GM) (p < 0.002 for LGG, and p < 0.02 for HGG). The dual echo ²³Na MRI suppressed the sodium signal within both CSF and necrotic foci.

Conclusion

Quantitative ²³Na MRI of pediatric gliomas demonstrates a range of values that are higher than non-neoplastic tissues. Dual echo ²³Na MRI of BCS improves tissue conspicuity relative to TSC imaging.

SUBMITTER: Bhatia A

PROVIDER: S-EPMC9140048 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Quantitative Sodium (<sup>23</sup>Na) MRI in Pediatric Gliomas: Initial Experience.

Bhatia Aashim A Lee Vincent Kyu VK Qian Yongxian Y Paldino Michael J MJ Ceschin Rafael R Hect Jasmine J Mountz James M JM Sun Dandan D Kohanbash Gary G Pollack Ian F IF Jakacki Regina I RI Boada Fernando F Panigrahy Ashok A

Diagnostics (Basel, Switzerland) 20220513 5

Background: 23Na MRI correlates with tumor proliferation, and studies in pediatric patients are lacking. The purpose of the study: (1) to compare total sodium concentration (TSC) between pediatric glioma and non-neoplastic brain tissue using 23Na MRI; (2) compare tissue conspicuity of bound sodium concentration (BSC) using 23Na MRI dual echo relative to TSC imaging. Methods: TSC was measured in: (1) non-neoplastic brain tissues and (2) three types of manually segmented gliomas (diffuse intrinsic ...[more]

PMID: 35626378

Similar Datasets

Project description:Sodium is crucial for the maintenance of cell physiology, and its regulation of the sodium-potassium pump has implications for various neurological conditions. The distribution of sodium concentrations in tissue can be quantitatively evaluated by means of sodium MRI (23 Na-MRI). Despite its usefulness in diagnosing particular disease conditions, tissue sodium concentration (TSC) estimated from 23 Na-MRI can be strongly biased by partial volume effects (PVEs) that are induced by broad point spread functions (PSFs) as well as tissue fraction effects. In this work, we aimed to propose a robust voxel-wise partial volume correction (PVC) method for 23 Na-MRI. The method is based on a linear regression (LR) approach to correct for tissue fraction effects, but it utilizes a 3D kernel combined with a modified least trimmed square (3D-mLTS) method in order to minimize regression-induced inherent smoothing effects. We acquired 23 Na-MRI data with conventional Cartesian sampling at 7 T, and spill-over effects due to the PSF were considered prior to correcting for tissue fraction effects using 3D-mLTS. In the simulation, we found that the TSCs of gray matter (GM) and white matter (WM) were underestimated by 20% and 11% respectively without correcting tissue fraction effects, but the differences between ground truth and PVE-corrected data after the PVC using the 3D-mLTS method were only approximately 0.6% and 0.4% for GM and WM, respectively. The capability of the 3D-mLTS method was further demonstrated with in vivo 23 Na-MRI data, showing significantly lower regression errors (ie root mean squared error) as compared with conventional LR methods (p < 0.001). The results of simulation and in vivo experiments revealed that 3D-mLTS is superior for determining under- or overestimated TSCs while preserving anatomical details. This suggests that the 3D-mLTS method is well suited for the accurate determination of TSC, especially in small focal lesions associated with pathological conditions.

Project description:ObjectivesTo determine the relaxation times of the sodium nucleus, and to investigate the repeatability of quantitative, in vivo TSC measurements using sodium magnetic resonance imaging (23Na-MRI) in human skeletal muscle and explore the discriminatory value of the method by comparing TSCs between healthy subjects and patients with Addison's disease.Materials and methodsIn this prospective study, ten healthy subjects and five patients with Addison's disease were involved. 23Na-MRI data sets were acquired using a density-adapted, three-dimensional radial projection reconstruction pulse sequence (DA-3DPR) with a modification for the relaxation times measurements. Differences in TSC between muscle groups and between healthy participants were analysed using a nonparametric Friedman ANOVA test. An interclass correlation coefficient (ICC) was used as the repeatability index. Wilcoxon rank sum test was used for evaluation of differences in TSC between study participants.ResultsThe mean T1 in the gastrocnemius medialis (GM), the tibialis anterior (TA), and the soleus (S) was 25.9 ± 2.0 ms, 27.6 ± 2.0 ms, and 28.2 ± 2.0 ms, respectively. The mean short component of T2*, T2*short were GM: 3.6 ± 2.0 ms; TA: 3.2 ± 0.5 ms; and S: 3.0 ± 1.0 ms, and the mean long component of T2*, T2*long, were GM: 12.9 ± 0.9 ms; TA: 12.8 ± 0.7 ms; and S: 12.9 ± 2.0 ms, respectively. In healthy volunteers, TSC values in the GM were 19.9 ±0.1 mmol/L, 13.8 ±0.2 mmol/L in TA, and 12.6 ± 0.2 mmol/L in S, and were significantly different (p = 0.0005). The ICCs for GM, TA and S were 0.784, 0.818, 0.807, respectively. In patients with Addison's disease, TSC in GC, TA, and S were 10.2 ± 1.0 mmol/L, 8.4 ± 0.6 mmol/L, and 7.2 ± 0.1 mmol/L, respectively.ConclusionsTSC quantification in a healthy subject's calf at 7.0 T is reliable; the technique is able to distinguish sodium level differences between muscles and between healthy subjects and Addison's disease patients.

Dataset Information

Quantitative Sodium (²³Na) MRI in Pediatric Gliomas: Initial Experience.

Background

The purpose of the study

Methods

Results

Conclusion

Publications

Quantitative Sodium (<sup>23</sup>Na) MRI in Pediatric Gliomas: Initial Experience.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Quantitative Sodium (23Na) MRI in Pediatric Gliomas: Initial Experience.

Background

The purpose of the study

Methods

Results

Conclusion

Publications

Quantitative Sodium (<sup>23</sup>Na) MRI in Pediatric Gliomas: Initial Experience.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Quantitative Sodium (²³Na) MRI in Pediatric Gliomas: Initial Experience.