Dataset Information

Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes.

ABSTRACT:

Background

To date, nearly 300 genetic markers were linked to endurance and power/strength traits. The current study aimed to compare genotype distributions and allele frequencies of the common polymorphisms: MCT1 rs1049434, NRF2 rs12594956, MYBPC3 rs1052373 and HFE rs1799945 in Polish elite athletes versus nonathletes.

Methods

The study involved 101 male elite Polish athletes and 41 healthy individuals from the Polish population as a control group. SNP data were extracted from whole-genome sequencing (WGS) performed using the following parameters: paired reads of 150 bps, at least 90 Gb of data per sample with 300 M reads and 30× mean coverage.

Results

All the analyzed polymorphisms conformed to Hardy-Weinberg equilibrium (HWE) in athletes and the control group, except the MCT1 rs1049434, where allele T was over-represented in the elite trainers' group. No significant between-group differences were found for analyzed polymorphisms.

Conclusions

The MCT1 rs1049434 transmission distortion might be characteristic of Polish athletes and the effect of strict inclusion criteria. This result and the lack of statistically significant changes in the frequency of other polymorphisms between the groups might result from the small group size.

SUBMITTER: Dzitkowska-Zabielska M

PROVIDER: S-EPMC9142056 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes.

Dzitkowska-Zabielska Magdalena M Bojarczuk Aleksandra A Borczyk Małgorzata M Piechota Marcin M Korostyński Michał M Adamczyk Jakub Grzegorz JG Trybek Grzegorz G Massidda Myosotis M Cięszczyk Paweł P

Genes 20220512 5

<h4>Background</h4>To date, nearly 300 genetic markers were linked to endurance and power/strength traits. The current study aimed to compare genotype distributions and allele frequencies of the common polymorphisms: <i>MCT1</i> rs1049434, <i>NRF2</i> rs12594956, <i>MYBPC3</i> rs1052373 and <i>HFE</i> rs1799945 in Polish elite athletes versus nonathletes.<h4>Methods</h4>The study involved 101 male elite Polish athletes and 41 healthy individuals from the Polish population as a control group. SNP ...[more]

PMID: 35627255

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Project description:Vitamin D does not only influence the musculoskeletal health and mineral homeostasis but it also affects cardiovascular, endocrine, nervous, immune and mental functions, thus it is of considerable importance for both physically active people and elite athletes. However, vitamin D deficiency is common worldwide and results from inadequate endogenous skin synthesis (insufficient ultraviolet B exposure) and diet. To improve the vitamin D status elite athletes often travel to lower latitude during winter. The aim of the study was to evaluate the seasonal vitamin D status in Polish elite athletes according to the sun exposure and oral supplementation. Serum concentration of 25-hydroxyvitamin D (25(OH)D) was measured in the years 2010-2014 in 409 elite athletes, who were divided into the following groups: OUTD-outdoor sports, represented by track and field athletes, who trained in Poland; IND-weightlifters, handball and volleyball players who trained indoors in Poland; SUN-track and field athletes who trained during Polish winter in lower latitude with high sunshine exposure; SUPL-track and field athletes who trained in Poland, had an inadequate vitamin D status (25(OH)D < 30 ng/ml) and were supplemented orally. Inadequate Vitamin D status was observed in 80% of OUTD and 84% of IND athletes in winter, whereas in summer the values amounted to 42% and 83%, respectively. The athletes exposed to sun in winter had significantly higher vitamin D concentration than OUTD group. Oral supplementation improved vitamin D concentration by 45%, whereas winter sun exposure caused its increase by 85%. Except for a few summer months an inadequate status of vitamin D was found in the majority of Polish elite athletes, with the deficiency level being similar to the one observed in non-athletic population. The most serious deficiency was observed in indoor disciplines. Adequate vitamin D status can be achieved by both increased sun exposure, especially in winter, and oral supplementation. Athletes should therefore routinely assess their vitamin D status and be educated how to approach their sunlight exposure, diet and supplementation.

Dataset Information

Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes.

Background

Methods

Results

Conclusions

Publications

Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes.

Similar Datasets

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