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Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development.

ABSTRACT: Lysyl oxidase-like 2 (LOXL2) and 3 (LOXL3) are members of the lysyl oxidase family of enzymes involved in the maturation of the extracellular matrix. Both enzymes share a highly conserved catalytic domain, but it is unclear whether they perform redundant functions in vivo. In this study, we show that mice lacking Loxl3 exhibit perinatal lethality and abnormal skeletal development. Additionally, analysis of the genotype of embryos carrying double knockout of Loxl2 and Loxl3 genes suggests that both enzymes have overlapping functions during mouse development. Furthermore, we also show that ubiquitous expression of Loxl2 suppresses the lethality associated with Loxl3 knockout mice.

SUBMITTER: Santamaria PG

PROVIDER: S-EPMC9144032 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development.

Santamaría Patricia G PG Dubus Pierre P Bustos-Tauler José J Floristán Alfredo A Vázquez-Naharro Alberto A Morales Saleta S Cano Amparo A Portillo Francisco F

International journal of molecular sciences 20220520 10

Lysyl oxidase-like 2 (LOXL2) and 3 (LOXL3) are members of the lysyl oxidase family of enzymes involved in the maturation of the extracellular matrix. Both enzymes share a highly conserved catalytic domain, but it is unclear whether they perform redundant functions in vivo. In this study, we show that mice lacking Loxl3 exhibit perinatal lethality and abnormal skeletal development. Additionally, analysis of the genotype of embryos carrying double knockout of <i>Loxl2</i> and <i>Loxl3</i> genes su ...[more]

PMID: 35628534

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