Ontology highlight
ABSTRACT:
SUBMITTER: McCarthy EE
PROVIDER: S-EPMC9151348 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
McCarthy Elizabeth E EE Odorizzi Pamela M PM Lutz Emma E Smullin Carolyn P CP Tenvooren Iliana I Stone Mars M Simmons Graham G Hunt Peter W PW Feeney Margaret E ME Norris Philip J PJ Busch Michael P MP Spitzer Matthew H MH Rutishauser Rachel L RL
Cell reports 20220501 7
Although generating high neutralizing antibody levels is a key component of protective immunity after acute viral infection or vaccination, little is known about why some individuals generate high versus low neutralizing antibody titers. Here, we leverage the high-dimensional single-cell profiling capacity of mass cytometry to characterize the longitudinal cellular immune response to Zika virus (ZIKV) infection in viremic blood donors in Puerto Rico. During acute ZIKV infection, we identify wide ...[more]