Ontology highlight
ABSTRACT:
SUBMITTER: Iulianna T
PROVIDER: S-EPMC9151667 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Iulianna Taritsa T Kuldeep Neote N Eric Fossel F
Cell death & disease 20220530 5
Interest in the lysosome's potential role in anticancer therapies has recently been appreciated in the field of immuno-oncology. Targeting lysosomes triggers apoptotic pathways, inhibits cytoprotective autophagy, and activates a unique form of apoptosis known as immunogenic cell death (ICD). This mechanism stimulates a local and systemic immune response against dead-cell antigens. Stressors that can lead to ICD include an abundance of ROS which induce lysosome membrane permeability (LMP). Dying ...[more]