Dataset Information

Ultrasound-Based Radiomics Can Classify the Etiology of Cervical Lymphadenopathy: A Multi-Center Retrospective Study.

ABSTRACT: Medical diagnostic imaging is essential for the differential diagnosis of cervical lymphadenopathy. Here we develop an ultrasound radiomics method for accurately differentiating cervical lymph node tuberculosis (LNTB), cervical lymphoma, reactive lymph node hyperplasia, and metastatic lymph nodes especially in the multi-operator, cross-machine, multicenter context. The inter-observer and intra-observer consistency of radiomics parameters from the region of interest were 0.8245 and 0.9228, respectively. The radiomics model showed good and repeatable diagnostic performance for multiple classification diagnosis of cervical lymphadenopathy, especially in LNTB (area under the curve, AUC: 0.673, 0.662, and 0.626) and cervical lymphoma (AUC: 0.623, 0.644, and 0.602) in the whole set, training set, and test set, respectively. However, the diagnostic performance of lymphadenopathy among skilled radiologists was varied (Kappa coefficient: 0.108, *p < 0.001). The diagnostic performance of radiomics is comparable and more reproducible compared with those of skilled radiologists. Our study offers a more comprehensive method for differentiating LNTB, cervical lymphoma, reactive lymph node hyperplasia, and metastatic LN.

SUBMITTER: Liu Y

PROVIDER: S-EPMC9152112 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Ultrasound-Based Radiomics Can Classify the Etiology of Cervical Lymphadenopathy: A Multi-Center Retrospective Study.

Liu Yajing Y Chen Jifan J Zhang Chao C Li Qunying Q Zhou Hang H Zeng Yiqing Y Zhang Ying Y Li Jia J Xv Wen W Li Wencun W Zhu Jianing J Zhao Yanan Y Chen Qin Q Huang Yi Y Li Hongming H Huang Ying Y Yang Gaoyi G Huang Pintong P

Frontiers in oncology 20220517

Medical diagnostic imaging is essential for the differential diagnosis of cervical lymphadenopathy. Here we develop an ultrasound radiomics method for accurately differentiating cervical lymph node tuberculosis (LNTB), cervical lymphoma, reactive lymph node hyperplasia, and metastatic lymph nodes especially in the multi-operator, cross-machine, multicenter context. The inter-observer and intra-observer consistency of radiomics parameters from the region of interest were 0.8245 and 0.9228, respec ...[more]

PMID: 35656511

Similar Datasets

Project description:BackgroundAccurate diagnosis of unexplained cervical lymphadenopathy (CLA) using medical images heavily relies on the experience of radiologists, which is even worse for CLA patients in underdeveloped countries and regions, because of lack of expertise and reliable medical history. This study aimed to develop a deep learning (DL) radiomics model based on B-mode and color Doppler ultrasound images for assisting radiologists to improve their diagnoses of the etiology of unexplained CLA.MethodsPatients with unexplained CLA who received ultrasound examinations from three hospitals located in underdeveloped areas of China were retrospectively enrolled. They were all pathologically confirmed with reactive hyperplasia, tuberculous lymphadenitis, lymphoma, or metastatic carcinoma. By mimicking the diagnosis logic of radiologists, three DL sub-models were developed to achieve the primary diagnosis of benign and malignant, the secondary diagnosis of reactive hyperplasia and tuberculous lymphadenitis in benign candidates, and of lymphoma and metastatic carcinoma in malignant candidates, respectively. Then, a CLA hierarchical diagnostic model (CLA-HDM) integrating all sub-models was proposed to classify the specific etiology of each unexplained CLA. The assistant effectiveness of CLA-HDM was assessed by comparing six radiologists between without and with using the DL-based classification and heatmap guidance.ResultsA total of 763 patients with unexplained CLA were enrolled and were split into the training cohort (n=395), internal testing cohort (n=171), and external testing cohorts 1 (n=105) and 2 (n=92). The CLA-HDM for diagnosing four common etiologies of unexplained CLA achieved AUCs of 0.873 (95% CI: 0.838-0.908), 0.837 (95% CI: 0.789-0.889), and 0.840 (95% CI: 0.789-0.898) in the three testing cohorts, respectively, which was systematically more accurate than all the participating radiologists. With its assistance, the accuracy, sensitivity, and specificity of six radiologists with different levels of experience were generally improved, reducing the false-negative rate of 2.2-10% and the false-positive rate of 0.7-3.1%.ConclusionsMulti-cohort testing demonstrated our DL model integrating dual-modality ultrasound images achieved accurate diagnosis of unexplained CLA. With its assistance, the gap between radiologists with different levels of experience was narrowed, which is potentially of great significance for benefiting CLA patients in underdeveloped countries and regions worldwide.

Project description:BackgroundThe precise prediction of multi-origin malignant cervical lymphadenopathy is limited by the low inter-reader reproducibility of imaging interpretation, and a quantitative method to improve this aspect is lacking. This study aimed to develop and validate an artificial intelligence framework integrating quantitative vascular features for assessing cervical lymphadenopathy and explore its utility among radiologists.MethodsFor this retrospective study, a total of 21,298 ultrasound images of 10,649 cervical lymph nodes (LNs) from 10,386 patients and 2366 images of 1183 LNs from 1151 patients at the Sun Yat-sen University Cancer Center between January 2011 and July 2022 were used for model development and internal testing, respectively. For external model testing, we used 776 images of 388 LNs from 360 patients at the Chongqing University Cancer Hospital between January and December 2022. Quantitative features used to characterize the vascular distribution and degree of richness were fused with morphological and semantic features on B-mode and color Doppler ultrasound images to develop a dual-modality, multi-feature, fusion lymph node network (DMFLNN). Subsequently, the performance of DMFLNN was compared with that of six radiologists, and its auxiliary value was assessed in test cohorts.FindingsDMFLNN achieved an area under the receiver operating characteristic curve (AUC) of 0.937 for the internal test cohort and 0.875 for the external test cohort. Using the internal test cohort with assistance from DMFLNN, the average AUC improved from 0.814 to 0.836 for senior radiologists (P = 0.00018), and from 0.778 to 0.847 for junior radiologists (P < 0.0001). Additionally, the average inter-radiologist agreement improved from fair to moderate (improvement in kappa: from 0.590 to 0.696 for senior radiologists; from 0.571 to 0.750 for junior radiologists). Similar trends were observed for the external test cohort. Moreover, the radiologists' average false-positive rate decreased by 3.8% and 9.8% for the internal and external test cohorts, respectively.InterpretationDMFLNN could improve radiologists' performance and potentially reduce unnecessary biopsies of cervical lymphadenopathy. However, further testing is warranted before its wide adoption in clinical practice.FundingThe National Natural Science Foundation of China (82171955; 62371476; 82441027); the China Department of Science and Technology (2023YFE0204300); and the R&D project of Pazhou Lab (HuangPu) (2023K0606).

Project description:BACKGROUND:This study aims to establish a radiomics analysis system for the diagnosis and clinical behaviour prediction of hepatocellular carcinoma (HCC) based on multi-parametric ultrasound imaging. METHODS:A total of 177 patients with focal liver lesions (FLLs) were included in the study. Every patient underwent multi-modal ultrasound examination, including B-mode ultrasound (BMUS), shear wave elastography (SWE), and shear wave viscosity (SWV) imaging. The radiomics analysis system was built on sparse representation theory (SRT) and support vector machine (SVM) for asymmetric data. Through the sparse regulation from the SRT, the proposed radiomics system can effectively avoid over-fitting issues that occur in regular radiomics analysis. The purpose of the proposed system includes differential diagnosis between benign and malignant FLLs, pathologic diagnosis of HCC, and clinical prognostic prediction. Three biomarkers, including programmed cell death protein 1 (PD-1), antigen Ki-67 (Ki-67) and microvascular invasion (MVI), were included and analysed. We calculated the accuracy (ACC), sensitivity (SENS), specificity (SPEC) and area under the receiver operating characteristic curve (AUC) to evaluate the performance of the radiomics models. RESULTS:A total of 2560 features were extracted from the multi-modal ultrasound images for each patient. Five radiomics models were built, and leave-one-out cross-validation (LOOCV) was used to evaluate the models. In LOOCV, the AUC was 0.94 for benign and malignant classification (95% confidence interval [CI]: 0.88 to 0.98), 0.97 for malignant subtyping (95% CI: 0.93 to 0.99), 0.97 for PD-1 prediction (95% CI: 0.89 to 0.98), 0.94 for Ki-67 prediction (95% CI: 0.87 to 0.97), and 0.98 for MVI prediction (95% CI: 0.93 to 0.99). The performance of each model improved when the viscosity modality was included. CONCLUSIONS:Radiomics analysis based on multi-modal ultrasound images could aid in comprehensive liver tumor evaluations, including diagnosis, differential diagnosis, and clinical prognosis.

Dataset Information

Ultrasound-Based Radiomics Can Classify the Etiology of Cervical Lymphadenopathy: A Multi-Center Retrospective Study.

Publications

Ultrasound-Based Radiomics Can Classify the Etiology of Cervical Lymphadenopathy: A Multi-Center Retrospective Study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets