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Expansion of L452R-Positive SARS-CoV-2 Omicron Variant, Northern Lombardy, Italy.

ABSTRACT: We report 25 cases of infection with SARS-CoV-2 Omicron variant containing spike protein L452R mutation in northern Lombardy, Italy. Prevalence of this variant was >30% in this region, compared with <0.5% worldwide. Many laboratories are using previously developed L452R-specific PCRs to discriminate Omicron from Delta mutations, but these tests may be unreliable.

SUBMITTER: Novazzi F

PROVIDER: S-EPMC9155861 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Expansion of L452R-Positive SARS-CoV-2 Omicron Variant, Northern Lombardy, Italy.

Novazzi Federica F Baj Andreina A Genoni Angelo A Focosi Daniele D Maggi Fabrizio F

Emerging infectious diseases 20220413 6

We report 25 cases of infection with SARS-CoV-2 Omicron variant containing spike protein L452R mutation in northern Lombardy, Italy. Prevalence of this variant was >30% in this region, compared with <0.5% worldwide. Many laboratories are using previously developed L452R-specific PCRs to discriminate Omicron from Delta mutations, but these tests may be unreliable. ...[more]

PMID: 35416767

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