Ontology highlight
ABSTRACT:
SUBMITTER: Priya S
PROVIDER: S-EPMC9159953 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Priya Sambhawa S Burns Michael B MB Ward Tonya T Mars Ruben A T RAT Adamowicz Beth B Lock Eric F EF Kashyap Purna C PC Knights Dan D Blekhman Ran R
Nature microbiology 20220516 6
While gut microbiome and host gene regulation independently contribute to gastrointestinal disorders, it is unclear how the two may interact to influence host pathophysiology. Here we developed a machine learning-based framework to jointly analyse paired host transcriptomic (n = 208) and gut microbiome (n = 208) profiles from colonic mucosal samples of patients with colorectal cancer, inflammatory bowel disease and irritable bowel syndrome. We identified associations between gut microbes and hos ...[more]