Dataset Information

Clinicodemographic profile and predictors of poor outcome in hospitalised COVID-19 patients: a single-centre, retrospective cohort study from India.

ABSTRACT:

Objectives

Primary objective was to study the clinicodemographic profile of hospitalised COVID-19 patients at a tertiary-care centre in India. Secondary objective was to identify predictors of poor outcome.

Setting

Single centre tertiary-care level.

Design

Retrospective cohort study.

Participants

Consecutively hospitalised adults patients with COVID-19.

Primary and secondary outcome measures

Primary outcome variable was in-hospital mortality. Covariables were known comorbidities, clinical features, vital signs at the time of admission and on days 3-5 of admission, and initial laboratory investigations.

Results

Intergroup differences were tested using χ² or Fischer's exact tests, Student's t-test or Mann-Whitney U test. Predictors of mortality were evaluated using multivariate logistic regression model. Out of 4102 SARS-CoV-2 positive patients admitted during 1-year period, 3268 (79.66%) survived to discharge and 834 (20.33%) died in the hospital. Mortality rates increased with age. Death was more common among males (OR 1.51, 95% CI 1.25 to 1.81). Out of 261 cases analysed in detail, 55.1% were in mild, 32.5% in moderate and 12.2% in severe triage category. Most common clinical presentations in the subgroup were fever (73.2%), cough/coryza (65.5%) and breathlessness (54%). Hypertension (45.2%), diabetes mellitus (41.8%) and chronic kidney disease (CKD; 6.1%) were common comorbidities. Disease severity on admission (adjusted OR 12.53, 95% CI 4.92 to 31.91, p<0.01), coagulation defect (33.21, 3.85-302.1, p<0.01), CKD (5.67, 1.08-29.64, p=0.04), high urea (11.05, 3.9-31.02, p<0.01), high prothrombin time (3.91, 1.59-9.65, p<0.01) and elevated ferritin (1.02, 1.00-1.03, p=0.02) were associated with poor outcome on multivariate regression. A strong predictor of mortality was disease progression on days 3-5 of admission (adjusted OR 13.66 95% CI 3.47 to 53.68).

Conclusion

COVID-19 related mortality in hospitalised adult patients at our center was similar to the developed countries. Progression in disease severity on days 3-5 of admission or days 6-13 of illness onset acts as 'turning point' for timely referral or treatment intensification for optimum use of resources.

SUBMITTER: Tiwari L

PROVIDER: S-EPMC9160596 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Clinicodemographic profile and predictors of poor outcome in hospitalised COVID-19 patients: a single-centre, retrospective cohort study from India.

Tiwari Lokesh L Gupta Prakriti P N Yankappa Y Banerjee Amrita A Kumar Yogesh Y Singh Prashant K PK Ranjan Alok A Singh C M CM Singh Prabhat Kumar PK

BMJ open 20220601 6

<h4>Objectives</h4>Primary objective was to study the clinicodemographic profile of hospitalised COVID-19 patients at a tertiary-care centre in India. Secondary objective was to identify predictors of poor outcome.<h4>Setting</h4>Single centre tertiary-care level.<h4>Design</h4>Retrospective cohort study.<h4>Participants</h4>Consecutively hospitalised adults patients with COVID-19.<h4>Primary and secondary outcome measures</h4>Primary outcome variable was in-hospital mortality. Covariables were ...[more]

PMID: 35649611

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Dataset Information

Clinicodemographic profile and predictors of poor outcome in hospitalised COVID-19 patients: a single-centre, retrospective cohort study from India.

Objectives

Setting

Design

Participants

Primary and secondary outcome measures

Results

Conclusion

Publications

Clinicodemographic profile and predictors of poor outcome in hospitalised COVID-19 patients: a single-centre, retrospective cohort study from India.

Similar Datasets

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