Pyroptosis-Related Gene Signature Predicts the Prognosis and Immune Infiltration in Neuroblastoma.
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ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC9162481 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Pyroptosis-Related Gene Signature Predicts the Prognosis and Immune Infiltration in Neuroblastoma.
Li Wanrong W Li Xin X Xia Yuren Y Wang Jian J
Frontiers in genetics 20220519
Neuroblastoma is the most common pediatric extracranial solid tumor. The 5-year survival rate for high-risk neuroblastoma is less than 50%, despite multimodal treatment. Pyroptosis, an inflammatory type of programmed cell death, manifested pro-tumor and anti-tumor roles in the adult tumor. Thus, we aimed to elucidate the function of pyroptosis in neuroblastoma. We classified neuroblastoma patients into two clusters based on the pyroptosis gene expression. We found high pyroptosis neuroblastoma m ...[more]
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