T cell responses during HBV and HCV infections: similar but not quite the same?
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ABSTRACT:
SUBMITTER: Shoukry NH
PROVIDER: S-EPMC9164221 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
T cell responses during HBV and HCV infections: similar but not quite the same?
Shoukry Naglaa H NH Walker Christopher M CM
Current opinion in virology 20211004
The hepatitis B and C viruses persist by evasion of T cell immunity. Persistence depends upon premature failure of CD4+ T cell help and loss of CD8+ T cell control because of epitope mutational escape and/or functional exhaustion. Powerful new immunological and transcriptomic tools provide insight into the mechanisms of T cell silencing by HBV and HCV. Similarities are apparent, including dysregulated expression of common inhibitory/immune checkpoint receptors and transcription factors. There ar ...[more]
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