Dataset Information

Forced Expiratory Flow at 25%-75% Links COPD Physiology to Emphysema and Disease Severity in the SPIROMICS Cohort.

ABSTRACT:

Background

Forced expiratory volume in 1 second (FEV₁) is central to the diagnosis of chronic obstructive pulmonary disease (COPD) but is imprecise in classifying disease burden. We examined the potential of the maximal mid-expiratory flow rate (forced expiratory flow rate between 25% and 75% [FEF_25%-75%]) as an additional tool for characterizing pathophysiology in COPD.

Objective

To determine whether FEF_25%-75% helps predict clinical and radiographic abnormalities in COPD.

Study design and methods

The SubPopulations and InteRediate Outcome Measures In COPD Study (SPIROMICS) enrolled a prospective cohort of 2978 nonsmokers and ever-smokers, with and without COPD, to identify phenotypes and intermediate markers of disease progression. We used baseline data from 2771 ever-smokers from the SPIROMICS cohort to identify associations between percent predicted FEF_25%-75% (%predFEF_25%-75%) and both clinical markers and computed tomography (CT) findings of smoking-related lung disease.

Results

Lower %predFEF_25-75% was associated with more severe disease, manifested radiographically by increased functional small airways disease, emphysema (most notably with homogeneous distribution), CT-measured residual volume, total lung capacity (TLC), and airway wall thickness, and clinically by increased symptoms, decreased 6-minute walk distance, and increased bronchodilator responsiveness (BDR). A lower %predFEF_25-75% remained significantly associated with increased emphysema, functional small airways disease, TLC, and BDR after adjustment for FEV₁ or forced vital capacity (FVC).

Interpretation

The %predFEF_25-75% provides additional information about disease manifestation beyond FEV₁. These associations may reflect loss of elastic recoil and air trapping from emphysema and intrinsic small airways disease. Thus, %predFEF_25-75% helps link the anatomic pathology and deranged physiology of COPD.

SUBMITTER: Ronish BE

PROVIDER: S-EPMC9166328 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Publications

Forced Expiratory Flow at 25%-75% Links COPD Physiology to Emphysema and Disease Severity in the SPIROMICS Cohort.

Ronish Bonnie E BE Couper David J DJ Barjaktarevic Igor Z IZ Cooper Christopher B CB Kanner Richard E RE Pirozzi Cheryl S CS Kim Victor V Wells James M JM Han MeiLan K MK Woodruff Prescott G PG Ortega Victor E VE Peters Stephen P SP Hoffman Eric A EA Buhr Russell G RG Dolezal Brett A BA Tashkin Donald P DP Liou Theodore G TG Bateman Lori A LA Schroeder Joyce D JD Martinez Fernando J FJ Barr R Graham RG Hansel Nadia N NN Comellas Alejandro P AP Rennard Stephen I SI Arjomandi Mehrdad M Paine Iii Robert R

Chronic obstructive pulmonary diseases (Miami, Fla.) 20220401 2

<h4>Background</h4>Forced expiratory volume in 1 second (FEV<sub>1</sub>) is central to the diagnosis of chronic obstructive pulmonary disease (COPD) but is imprecise in classifying disease burden. We examined the potential of the maximal mid-expiratory flow rate (forced expiratory flow rate between 25% and 75% [FEF<sub>25%-75%</sub>]) as an additional tool for characterizing pathophysiology in COPD.<h4>Objective</h4>To determine whether FEF<sub>25%-75%</sub> helps predict clinical and radiograp ...[more]

PMID: 35114743

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Project description:ObjectivesThe aim of this study was to assess the prevalence and determinants of post-tuberculosis chronic respiratory signs, as well as the clinical impact of a low forced expiratory flow between 25% and 75% (FEF25-75%) in a group of individuals previously treated successfully for pulmonary tuberculosis.DesignThis was a cross-sectional study involving individuals in their post-tuberculosis treatment period. They all underwent a spirometry following the 2005 criteria of the American Thoracic Society/European Respiratory Society. Distal airflow obstruction (DAO) was defined by an FEF25-75% <65% and a ratio forced expiratory volume during the first second (FEV1)/forced vital capacity (FVC) ? 0.70. Logistic regression models were used to investigate the determinants of persisting respiratory symptoms following antituberculous treatment.SettingThis study was carried out in the tuberculosis diagnosis and treatment centre at Yaounde Jamot Hospital, which serves as a referral centre for tuberculosis and respiratory diseases for the capital city of Cameroon (Yaounde) and surrounding areas.ParticipantsAll consecutive patients in their post-tuberculosis treatment period were consecutively enrolled between November 2012 and April 2013.ResultsOf the 177 patients included, 101 (57.1%) were men, whose median age (25th-75th centiles) was 32 (24-45.5) years. At least one chronic respiratory sign was present in 110 (62.1%) participants and DAO was found in 67 (62.9%). Independent determinants of persisting respiratory signs were the duration of symptoms prior to tuberculosis diagnosis higher than 12?weeks (adjusted OR 2.91; 95% CI 1.12 to 7.60, p=0.029) and presence of DAO (2.22; 1.13 to 4.38, p=0.021).ConclusionsFEF25-75%<65% is useful for the assessment and diagnosis of post-tuberculous DAO. Mass education targeting early diagnosis of pulmonary tuberculosis can potentially reduce the prevalence of post-tuberculosis respiratory signs and distal airflow obstruction.

Project description:BackgroundThe assumption that the assessment of forced expiratory flow between 25% and 75% of vital capacity (FEF(25-75)) does not provide additional information in asthmatic children with normal FEV(1) percent predicted has not been adequately tested.ObjectiveWe sought to determine whether the measurement of FEF(25-75) percent predicted offers advantages over FEV(1) percent predicted and FEV(1)/forced vital capacity (FVC) percent predicted for the evaluation of childhood asthma.MethodsThis is a secondary analysis of data from the Pediatric Asthma Controller Trial and the Characterizing the Response to a Leukotriene Receptor Antagonist and Inhaled Corticosteroid trials. Pearson correlation coefficients, Pearson partial correlation coefficients, canonical correlations, and receiver operating characteristic (ROC) curves were constructed.ResultsAmong 437 children with normal FEV(1) percent predicted, FEF(25-75) percent predicted, and FEV(1)/FVC percent predicted were (1) positively correlated with log(2) methacholine PC(20), (2) positively correlated with morning and evening peak expiratory flow percent predicted, and (3) negatively correlated with log(10) fraction of exhaled nitric oxide and bronchodilator responsiveness. Pearson partial correlations and canonical correlations indicated that FEF(25-75) percent predicted was better correlated with bronchodilator responsiveness and log(2) methacholine PC(20) than were FEV(1) percent predicted or FEV(1)/FVC percent predicted. In the ROC curve analysis, FEF(25-75) at 65% of predicted value had a 90% sensitivity and a 67% specificity for detecting a 20% increase in FEV(1) after albuterol inhalation.ConclusionFEF(25-75) percent predicted was well correlated with bronchodilator responsiveness in asthmatic children with normal FEV(1). FEF(25-75) percent predicted should be evaluated in clinical studies of asthma in children and might be of use in predicting the presence of clinically relevant reversible airflow obstruction.

Dataset Information

Forced Expiratory Flow at 25%-75% Links COPD Physiology to Emphysema and Disease Severity in the SPIROMICS Cohort.

Background

Objective

Study design and methods

Results

Interpretation

Publications

Forced Expiratory Flow at 25%-75% Links COPD Physiology to Emphysema and Disease Severity in the SPIROMICS Cohort.

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