Ontology highlight
ABSTRACT:
SUBMITTER: Jiang C
PROVIDER: S-EPMC9168196 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Jiang Chang C Ward Nathan P NP Prieto-Farigua Nicolas N Kang Yun Pyo YP Thalakola Anish A Teng Mingxiang M DeNicola Gina M GM
Redox biology 20220602
The redox regulator NRF2 is hyperactivated in a large percentage of non-small cell lung cancer (NSCLC) cases, which is associated with chemotherapy and radiation resistance. To identify redox vulnerabilities for KEAP1/NRF2 mutant NSCLC, we conducted a CRISPR-Cas9-based negative selection screen for antioxidant enzyme genes whose loss sensitized cells to sub-lethal concentrations of the superoxide (O<sub>2</sub><sup>•</sup><sup>-</sup>) -generating drug β-Lapachone. While our screen identified ex ...[more]