Protein cost minimization promotes the emergence of coenzyme redundancy.
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ABSTRACT:
SUBMITTER: Goldford JE
PROVIDER: S-EPMC9168515 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Publications
Protein cost minimization promotes the emergence of coenzyme redundancy.
Goldford Joshua E JE George Ashish B AB Flamholz Avi I AI Segrè Daniel D
Proceedings of the National Academy of Sciences of the United States of America 20220328 14
SignificanceMetabolism relies on a small class of molecules (coenzymes) that serve as universal donors and acceptors of key chemical groups and electrons. Although metabolic networks crucially depend on structurally redundant coenzymes [e.g., NAD(H) and NADP(H)] associated with different enzymes, the criteria that led to the emergence of this redundancy remain poorly understood. Our combination of modeling and structural and sequence analysis indicates that coenzyme redundancy may not be essenti ...[more]
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