Orbitofrontal cortex governs working memory for temporal order.
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ABSTRACT:
SUBMITTER: Johnson EL
PROVIDER: S-EPMC9169582 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
Orbitofrontal cortex governs working memory for temporal order.
Johnson Elizabeth L EL Chang William K WK Dewar Callum D CD Sorensen Donna D Lin Jack J JJ Solbakk Anne-Kristin AK Endestad Tor T Larsson Pal G PG Ivanovic Jugoslav J Meling Torstein R TR Scabini Donatella D Knight Robert T RT
Current biology : CB 20220501 9
How do we think about time? Converging lesion and neuroimaging evidence indicates that orbitofrontal cortex (OFC) supports the encoding and retrieval of temporal context in long-term memory<sup>1</sup>, which may contribute to confabulation in individuals with OFC damage<sup>2</sup>. Here, we reveal that OFC damage diminishes working memory for temporal order, that is, the ability to disentangle the relative recency of events as they unfold. OFC lesions reduced working memory for temporal order ...[more]
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