Ontology highlight
ABSTRACT:
SUBMITTER: Bi Y
PROVIDER: S-EPMC9174176 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Nature communications 20220607 1
Human naive pluripotent stem cells offer a unique window into early embryogenesis studies. Recent studies have reported several strategies to obtain cells in the naive state. However, cell fate transitions and the underlying mechanisms remain poorly understood. Here, by a dual fluorescent reporter system, we depict the cell fate dynamics from primed state toward naive pluripotency with ALPG activation followed by the activation of OCT4-distal enhancer. Integration of transcription profiles and t ...[more]