Reversible bacteriophage resistance by shedding the bacterial cell wall.
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ABSTRACT:
SUBMITTER: Ongenae V
PROVIDER: S-EPMC9174709 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Publications
Reversible bacteriophage resistance by shedding the bacterial cell wall.
Ongenae Véronique V Mabrouk Adam Sidi AS Crooijmans Marjolein M Rozen Daniel D Briegel Ariane A Claessen Dennis D
Open biology 20220608 6
Phages are highly abundant in the environment and pose a major threat for bacteria. Therefore, bacteria have evolved sophisticated defence systems to withstand phage attacks. Here, we describe a previously unknown mechanism by which mono- and diderm bacteria survive infection with diverse lytic phages. Phage exposure leads to a rapid and near-complete conversion of walled cells to a cell-wall-deficient state, which remains viable in osmoprotective conditions and can revert to the walled state. W ...[more]
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