Unknown

Dataset Information

0

Olverembatinib inhibits SARS-CoV-2-Omicron variant-mediated cytokine release in human peripheral blood mononuclear cells.

ABSTRACT: The N-terminus domain (NTD) of the SARS-CoV-2 Omicron variant spike protien strongly induces multiple inflammatory molecules in human peripheral blood mononuclear cells, unaffected by the mutations observed in the NTD. Olverembatinib, a clinical-stage multi-kinase inhibitor, potently inhibits Omicron NTD-mediated cytokine release.

SUBMITTER: Chan M 

PROVIDER: S-EPMC9174875 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Olverembatinib inhibits SARS-CoV-2-Omicron variant-mediated cytokine release in human peripheral blood mononuclear cells.

Chan Marina M   Holland Eric C EC   Gujral Taranjit S TS  

EMBO molecular medicine 20220517 6

The N-terminus domain (NTD) of the SARS-CoV-2 Omicron variant spike protien strongly induces multiple inflammatory molecules in human peripheral blood mononuclear cells, unaffected by the mutations observed in the NTD. Olverembatinib, a clinical-stage multi-kinase inhibitor, potently inhibits Omicron NTD-mediated cytokine release. ...[more]

Similar Datasets

Unknown mouse ACE2 receptor bound to SARS-CoV-2 variant Omicron BA.2.12.1 Spike
| EMPIAR-11180 | biostudies-other
Unknown mouse ACE2 receptor bound to SARS-CoV-2 variant Omicron BA.1 Spike
| EMPIAR-11179 | biostudies-other
Unknown Vaccine booster efficiently inhibits entry of SARS-CoV-2 omicron variant.
| S-EPMC8785151 | biostudies-literature
Unknown human ACE2 receptor bound to SARS-CoV-2 variant Omicron BA.4/5 Spike
| EMPIAR-11176 | biostudies-other
Unknown mouse ACE2 receptor bound to SARS-CoV-2 variant Omicron BA.4/5 Spike
| EMPIAR-11177 | biostudies-other
Unknown SARS-CoV-2 S Omicron Spike B.1.1.529
| EMPIAR-10947 | biostudies-other
Other Profiling of human monoclonal antibodies targeting SARS-CoV-2 Omicron variant
2022-07-01 | GSE203030 | GEO
Unknown Single-particle cryo-EM unaligned micrographs of prefusion SARS-CoV-2 spike omicron B.1.1.529 variant
| EMPIAR-11871 | biostudies-other
Unknown SARS-CoV-2 Omicron variant: Characteristics and prevention.
| S-EPMC8693031 | biostudies-literature
Unknown Determinants of reinfection with SARS-CoV-2 Omicron variant.
| S-EPMC10256591 | biostudies-literature