Ontology highlight
ABSTRACT:
SUBMITTER: Kraehenbuehl L
PROVIDER: S-EPMC9179243 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Kraehenbuehl Lukas L Holland Aliya A Armstrong Emma E O'Shea Sirinya S Mangarin Levi L Chekalil Sara S Johnston Amanda A Bomalaski John S JS Erinjeri Joseph P JP Barker Christopher A CA Francis Jasmine H JH Wolchok Jedd D JD Merghoub Taha T Shoushtari Alexander N AN
Cancers 20220526 11
Metastatic uveal melanoma (UM) remains challenging to treat, with objective response rates to immune checkpoint blockade (ICB) being much lower than in primary cutaneous melanoma (CM). Besides a lower mutational burden, the overall immune-excluded tumor microenvironment of UM might contribute to the poor response rate. We therefore aimed at targeting deficiency in argininosuccinate synthase 1, which is a key metabolic feature of UM. This study aims at investigating the safety and tolerability of ...[more]