Glioblastoma Stem-like Cell Detection Using Perfusion and Diffusion MRI.

ABSTRACT:

Purpose

With current gold standard treatment, which associates maximum safe surgery and chemo-radiation, the large majority of glioblastoma patients relapse within a year in the peritumoral non contrast-enhanced region (NCE). A subpopulation of glioblastoma stem-like cells (GSC) are known to be particularly radio-resistant and aggressive, and are thus suspected to be the cause of these relapses. Previous studies have shown that their distribution is heterogeneous in the NCE compartment, but no study exists on the sensitivity of medical imaging for localizing these cells. In this work, we propose to study the magnetic resonance (MR) signature of these infiltrative cells.

Methods

In the context of a clinical trial on 16 glioblastoma patients, relative Cerebral Blood Volume (rC

SUBMITTER: Duval T 

PROVIDER: S-EPMC9179449 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature