Copper Handling in the Salmonella Cell Envelope and Its Impact on Virulence.
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ABSTRACT:
SUBMITTER: Checa SK
PROVIDER: S-EPMC9185223 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Copper Handling in the Salmonella Cell Envelope and Its Impact on Virulence.
Checa Susana K SK Giri Germán F GF Espariz Martín M Argüello José M JM Soncini Fernando C FC
Trends in microbiology 20210127 5
Copper (Cu) plays a key role at the host-pathogen interface as both an essential element and a toxic element. Intracellular strains of pathogenic Salmonella have acquired the periplasmic Cu chaperone, CueP, and the thiol oxidoreductases complex Scs, while losing the ancestral Cu-detoxification Cus system. Coregulation of these species-specific factors link Cu with redox stress and allows Salmonella to counteract Cu toxicity during infection. ...[more]
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