The Evolution of Widespread Recombination Suppression on the Dwarf Hamster (Phodopus) X Chromosome.

ABSTRACT: The X chromosome of therian mammals shows strong conservation among distantly related species, limiting insights into the distinct selective processes that have shaped sex chromosome evolution. We constructed a chromosome-scale de novo genome assembly for the Siberian dwarf hamster (Phodopus sungorus), a species reported to show extensive recombination suppression across an entire arm of the X chromosome. Combining a physical genome assembly based on shotgun and long-range proximity ligation sequencing with a dense genetic map, we detected widespread suppression of female recombination across ∼65% of the Phodopus X chromosome. This region of suppressed recombination likely corresponds to the Xp arm, which has previously been shown to be highly heterochromatic. Using additional sequencing d

SUBMITTER: Moore EC 

PROVIDER: S-EPMC9185382 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature